Photodegradable Antimicrobial Agents: Synthesis and Mechanism of Degradation
Journal article, Peer reviewed
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OriginalversjonJournal of Organic Chemistry. 2022, 87, 8034-8047. 10.1021/acs.joc.2c00681
As a strategy to inactivate antimicrobial agents after use, we designed a range of ethanolamine derivatives where four of them possessed interesting activity. The ethanolamine moiety facilitates photodecomposition, which in a potential drug will take place after use. Herein, the synthetic preparation of these compounds and the mechanism of photoinactivation are described.