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dc.contributor.authorJones, Paul Remy
dc.contributor.authorRajalahti, Tarja
dc.contributor.authorResaland, Geir Kåre
dc.contributor.authorAadland, Eivind
dc.contributor.authorSteene-Johannessen, Jostein
dc.contributor.authorAnderssen, Sigmund Alfred
dc.contributor.authorBathen, Tone Frost
dc.contributor.authorAndreassen, Trygve
dc.contributor.authorKvalheim, Olav Martin
dc.contributor.authorEkelund, Ulf
dc.description.abstractBackground: Our understanding of the mechanisms through which physical activity might benefit lipoprotein metabolism is inadequate. Here we characterise the continuous associations between physical activity of different intensities, sedentary time, and a comprehensive lipoprotein particle profile. Methods: Our cohort included 762 fifth grade (mean [SD] age = 10.0 [0.3] y) Norwegian schoolchildren (49.6% girls) measured on two separate occasions across one school year. We used targeted proton nuclear magnetic resonance (1H NMR) spectroscopy to produce 57 lipoprotein measures from fasted blood serum samples. The children wore accelerometers for seven consecutive days to record time spent in light-, moderate-, and vigorous-intensity physical activity, and sedentary time. We used separate multivariable linear regression models to analyse associations between the device-measured activity variables—modelled both prospectively (baseline value) and as change scores (follow-up minus baseline value)—and each lipoprotein measure at follow-up. Results: Higher baseline levels of moderate-intensity and vigorous-intensity physical activity were associated with a favourable lipoprotein particle profile at follow-up. The strongest associations were with the larger subclasses of triglyceride-rich lipoproteins. Sedentary time was associated with an unfavourable lipoprotein particle profile, the pattern of associations being the inverse of those in the moderate-intensity and vigorous-intensity physical activity analyses. The associations with light-intensity physical activity were more modest; those of the change models were weak. Conclusion: We provide evidence of a prospective association between time spent active or sedentary and lipoprotein metabolism in schoolchildren. Change in activity levels across the school year is of limited influence in our young, healthy cohort.en_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleAssociations of lipoprotein particle profile and objectively measured physical activity and sedentary time in schoolchildren: a prospective cohort studyen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holderCopyright 2022 the authorsen_US
dc.source.journalInternational Journal of Behavioral Nutrition and Physical Activityen_US
dc.identifier.citationInternational Journal of Behavioral Nutrition and Physical Activity. 2022, 19, 5.en_US

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Navngivelse 4.0 Internasjonal
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