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dc.contributor.authorNielsen, Hans Jørgen
dc.contributor.authorNedrebø, Bjørn Gunnar
dc.contributor.authorFosså, Alexander
dc.contributor.authorAndersen, John Roger
dc.contributor.authorAssmus, Jörg
dc.contributor.authorDagsland, Vigdis Halvorsen
dc.contributor.authorDankel, Simon N
dc.contributor.authorGudbrandsen, Oddrun Anita
dc.contributor.authorFernø, Johan
dc.contributor.authorHjellestad, Iren Drange
dc.contributor.authorHjermstad, Marianne Jensen
dc.contributor.authorKolotkin, Ronette Loganzo
dc.contributor.authorThorsen, Håvard Luong
dc.contributor.authorMellgren, Gunnar
dc.contributor.authorFlølo, Tone Nygaard
dc.date.accessioned2022-08-12T11:46:46Z
dc.date.available2022-08-12T11:46:46Z
dc.date.created2022-05-09T15:04:43Z
dc.date.issued2022
dc.identifier.issn0307-0565
dc.identifier.urihttps://hdl.handle.net/11250/3011638
dc.description.abstractBackground/objectives There is limited long-term data comparing the outcomes of sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) for severe obesity, both with respect to body weight, quality of life (QOL) and comorbidities. We aimed to determine 7-year trajectories of body mass index (BMI), QOL, obesity-related comorbidities, biomarkers of glucose and lipid metabolism, and early major complications after SG and RYGB. Subjects/methods Patients scheduled for bariatric surgery at two Norwegian hospitals, preferentially performing either SG or RYGB, were included consecutively from September 2011 to February 2015. Data was collected prospectively before and up to 7 years after surgery. Obesity-specific, generic and overall QOL were measured by the Impact of Weight on Quality of Life-Lite, Short-Form 36 and Cantril’s ladder, respectively. Comorbidities were assessed by clinical examination, registration of medication and analysis of glucose and lipid biomarkers. Outcomes were examined with linear mixed effect models and relative risk estimates. Results Of 580 included patients, 543 (75% women, mean age 42.3 years, mean baseline BMI 43.0 kg/m2) were operated (376 SG and 167 RYGB). With 84.2% of participants evaluable after 5–7 years, model-based percent total weight-loss (%TWL) at 7 years was 23.4 after SG versus 27.3 after RYGB (difference 3.9%, p = 0.001). All levels of QOL improved similarly after the two surgical procedures but remained below reference data from the general population at all timepoints. Remission rates for type 2 diabetes, dyslipidemia, obstructive sleep-apnea and gastroesophageal reflux disease (GERD) as well as the rate of de novo GERD significantly favored RYGB. SG had fewer major early complications, but more minor and major late complications combined over follow-up. Conclusion In routine health care, both SG and RYGB are safe procedures with significant long-term weight-loss, improvement of QOL and amelioration of comorbidities. Long-term weight-loss and remission rates of main obesity-related comorbidities were higher after RYGB.en_US
dc.language.isoengen_US
dc.publisherNatureen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleSeven-year trajectories of body weight, quality of life and comorbidities following Roux-en-Y gastric bypass and sleeve gastrectomyen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2
dc.identifier.doi10.1038/s41366-021-01028-5
dc.identifier.cristin2022800
dc.source.journalInternational Journal of Obesityen_US
dc.source.pagenumber739-749en_US
dc.identifier.citationInternational Journal of Obesity. 2022, 46 (4), 739-749.en_US
dc.source.volume46en_US
dc.source.issue4en_US


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