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dc.contributor.authorFlønes, Irene Hana
dc.contributor.authorTzoulis, Charalampos
dc.date.accessioned2022-08-15T08:14:45Z
dc.date.available2022-08-15T08:14:45Z
dc.date.created2022-05-13T17:23:21Z
dc.date.issued2022
dc.identifier.issn2296-634X
dc.identifier.urihttps://hdl.handle.net/11250/3011773
dc.description.abstractParkinson’s disease (PD) is the most common age-dependent neurodegenerative synucleinopathy. Loss of dopaminergic neurons of the substantia nigra pars compacta, together with region- and cell-specific aggregations of α-synuclein are considered main pathological hallmarks of PD, but its etiopathogenesis remains largely unknown. Mitochondrial dysfunction, in particular quantitative and/or functional deficiencies of the mitochondrial respiratory chain (MRC), has been associated with the disease. However, after decades of research in this field, the pervasiveness and anatomical extent of MRC dysfunction in PD remain largely unknown. Moreover, it is not known whether the observed MRC defects are pathogenic, compensatory responses, or secondary epiphenomena. In this perspective, we give an overview of current evidence for MRC dysfunction in PD, highlight pertinent knowledge gaps, and propose potential strategies for future research.en_US
dc.language.isoengen_US
dc.publisherFrontiersen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleMitochondrial respiratory chain dysfunction—A hallmark pathology of idiopathic Parkinson’s disease?en_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.source.articlenumber874596en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.doi10.3389/fcell.2022.874596
dc.identifier.cristin2024519
dc.source.journalFrontiers in Cell and Developmental Biologyen_US
dc.identifier.citationFrontiers in Cell and Developmental Biology. 2022, 10, 874596.en_US
dc.source.volume10en_US


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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal