dc.contributor.author | Sagberg, Lisa Millgård | |
dc.contributor.author | Fyllingen, Even Hovig | |
dc.contributor.author | Hansen, Tor Ivar | |
dc.contributor.author | Strand, Per Sveino | |
dc.contributor.author | Håvik, Aril Løge | |
dc.contributor.author | Sundstrøm, Terje | |
dc.contributor.author | Corell, Alba | |
dc.contributor.author | Jakola, Asgeir Store | |
dc.contributor.author | Salvesen, Øyvind | |
dc.contributor.author | Solheim, Ole | |
dc.date.accessioned | 2022-09-28T12:43:15Z | |
dc.date.available | 2022-09-28T12:43:15Z | |
dc.date.created | 2022-08-29T14:17:42Z | |
dc.date.issued | 2022 | |
dc.identifier.issn | 0167-594X | |
dc.identifier.uri | https://hdl.handle.net/11250/3022289 | |
dc.description.abstract | Purpose
Risk of cancer has been associated with body or organ size in several studies. We sought to investigate the relationship between intracranial volume (ICV) (as a proxy for lifetime maximum brain size) and risk of IDH-mutant low-grade glioma.
Methods
In a multicenter case–control study based on population-based data, we included 154 patients with IDH-mutant WHO grade 2 glioma and 995 healthy controls. ICV in both groups was calculated from 3D MRI brain scans using an automated reverse brain mask method, and then compared using a binomial logistic regression model.
Results
We found a non-linear association between ICV and risk of glioma with increasing risk above and below a threshold of 1394 ml (p < 0.001). After adjusting for ICV, sex was not a risk factor for glioma.
Conclusion
Intracranial volume may be a risk factor for IDH-mutant low-grade glioma, but the relationship seems to be non-linear with increased risk both above and below a threshold in intracranial volume. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Springer | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Is intracranial volume a risk factor for IDH-mutant low-grade glioma? A case-control study | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2022 The Author(s) | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.doi | 10.1007/s11060-022-04120-6 | |
dc.identifier.cristin | 2046801 | |
dc.source.journal | Journal of Neuro-Oncology | en_US |
dc.identifier.citation | Journal of Neuro-Oncology. 2022. | en_US |