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dc.contributor.authorWoock, Malin
dc.contributor.authorMartinez-Majander, Nicolas
dc.contributor.authorSeiffge, David J.
dc.contributor.authorSelvik, Henriette Aurora
dc.contributor.authorNordanstig, Annika
dc.contributor.authorRedfors, Petra
dc.contributor.authorLindgren, Erik
dc.contributor.authorSanchez van Kammen, Mayte
dc.contributor.authorRentzos, Alexandros
dc.contributor.authorCoutinho, Jonathan M.
dc.contributor.authorDoyle, Karen
dc.contributor.authorNæss, Halvor
dc.contributor.authorPutaala, Jukka
dc.contributor.authorJood, Katarina
dc.contributor.authorTatlisumak, Turgut
dc.date.accessioned2022-09-30T12:31:42Z
dc.date.available2022-09-30T12:31:42Z
dc.date.created2022-09-15T14:49:45Z
dc.date.issued2022
dc.identifier.issn1756-2856
dc.identifier.urihttps://hdl.handle.net/11250/3022934
dc.description.abstractThe association between stroke and cancer is well-established. Because of an aging population and longer survival rates, the frequency of synchronous stroke and cancer will become even more common. Different pathophysiologic mechanisms have been proposed how cancer or cancer treatment directly or via coagulation disturbances can mediate stroke. Increased serum levels of D-dimer, fibrin degradation products, and CRP are more often seen in stroke with concomitant cancer, and the clot retrieved during thrombectomy has a more fibrin- and platelet-rich constitution compared with that of atherosclerotic etiology. Multiple infarctions are more common in patients with active cancer compared with those without a cancer diagnosis. New MRI techniques may help in detecting typical patterns seen in the presence of a concomitant cancer. In ischemic stroke patients, a newly published cancer probability score can help clinicians in their decision-making when to suspect an underlying malignancy in a stroke patient and to start cancer-screening studies. Treating stroke patients with synchronous cancer can be a delicate matter. Limited evidence suggests that administration of intravenous thrombolysis appears safe in non-axial intracranial and non-metastatic cancer patients. Endovascular thrombectomy is probably rather safe in these patients, but probably futile in most patients placed on palliative care due to their advanced disease. In this topical review, we discuss the epidemiology, pathophysiology, and prognosis of ischemic and hemorrhagic strokes as well as cerebral venous thrombosis and concomitant cancer. We further summarize the current evidence on acute management and secondary preventive therapy.en_US
dc.language.isoengen_US
dc.publisherSageen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleCancer and stroke: commonly encountered by clinicians, but little evidence to guide clinical approachen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.doi10.1177/17562864221106362
dc.identifier.cristin2052130
dc.source.journalTherapeutic Advances in Neurological Disorders (TAND)en_US
dc.source.pagenumber1-18en_US
dc.identifier.citationTherapeutic Advances in Neurological Disorders (TAND). 2022, 15, 1-18.en_US
dc.source.volume15en_US


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