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dc.contributor.authorBråten, Lars Christian Haugli
dc.contributor.authorGrøvle, Lars
dc.contributor.authorWigemyr, Monica
dc.contributor.authorWilhelmsen, Maja
dc.contributor.authorGjefsen, Elisabeth
dc.contributor.authorEspeland, Ansgar
dc.contributor.authorHaugen, Anne Julsrud
dc.contributor.authorSkouen, Jan Sture
dc.contributor.authorBrox, Jens Ivar
dc.contributor.authorZwart, John Anker Henrik
dc.contributor.authorStorheim, Kjersti
dc.contributor.authorOstelo, Raymond WJG.
dc.contributor.authorGrotle, Margreth
dc.description.abstractObjectives: The objective of this study was to estimate the minimal important change (MIC) and responsiveness of core patient reported outcome measures for chronic low back pain (LBP) and Modic changes. Study Design and Setting: In the Antibiotics in Modic changes (AIM) trial we measured disability (RMDQ, ODI), LBP intensity (NRS) and health-related quality of life (EQ5D) electronically at baseline, three- and 12-month follow-up. MICs were estimated using Receiver Operating Curve (ROC) curve and Predictive modeling analyses against the global perceived effect. Credibility of the estimates was assessed by a standardized set of criteria. Responsiveness was assessed by a construct and criterion approach according to COSMIN guidelines. Results: The MIC estimates of RMDQ, ODI and NRS scores varied between a 15–40% reduction, depending on including “slightly improved” in the definition of MIC or not. The MIC estimates for EQ5D were lower. The credibility of the estimates was moderate. For responsiveness, five out of six hypotheses were confirmed and AUC was >0.7 for all PROMs. Conclusion: When evaluated in a clinical trial of patients with chronic LBP and Modic changes, MIC thresholds for all PROMs were on the lower spectrum of previous estimates, varying depending on the definition of MIC. Responsiveness was sufficient.en_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleMinimal important change was on the lower spectrum of previous estimates and responsiveness was sufficient for core outcomes in chronic low back painen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holderCopyright 2022 the authorsen_US
dc.source.journalJournal of Clinical Epidemiologyen_US
dc.identifier.citationJournal of Clinical Epidemiology. 2022, 151, 75-87.en_US

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal