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dc.contributor.authorBarrett, James E.
dc.contributor.authorHerzog, Chiara
dc.contributor.authorJones, Allison
dc.contributor.authorLeavy, Olivia C.
dc.contributor.authorEvans, Iona
dc.contributor.authorKnapp, Susanne
dc.contributor.authorReisel, Daniel
dc.contributor.authorNazarenko, Tatiana
dc.contributor.authorKim, Yoo-Na
dc.contributor.authorFranchi, Dorella
dc.contributor.authorRyan, Andy
dc.contributor.authorFranks, Joanna
dc.contributor.authorBjørge, Line
dc.contributor.authorZikan, Michal
dc.contributor.authorCibula, David
dc.contributor.authorHarbeck, Nadia
dc.contributor.authorColombo, Nicoletta
dc.contributor.authorDudbridge, Frank
dc.contributor.authorJones, Louise
dc.contributor.authorSundström, Karin
dc.contributor.authorDillner, Joakim
dc.contributor.authorRådestad, Angelique Flöter
dc.contributor.authorGemzell-Danielsson, Kristina
dc.contributor.authorPashayan, Nora
dc.contributor.authorWidschwendter, Martin
dc.date.accessioned2022-10-10T12:09:13Z
dc.date.available2022-10-10T12:09:13Z
dc.date.created2022-05-19T13:31:44Z
dc.date.issued2022
dc.identifier.issn2041-1723
dc.identifier.urihttps://hdl.handle.net/11250/3025110
dc.description.abstractGenetic and non-genetic factors contribute to breast cancer development. An epigenome-based signature capturing these components in easily accessible samples could identify women at risk. Here, we analyse the DNA methylome in 2,818 cervical, 357 and 227 matched buccal and blood samples respectively, and 42 breast tissue samples from women with and without breast cancer. Utilising cervical liquid-based cytology samples, we develop the DNA methylation-based Women’s risk IDentification for Breast Cancer index (WID-BC-index) that identifies women with breast cancer with an AUROC (Area Under the Receiver Operator Characteristic) of 0.84 (95% CI: 0.80–0.88) and 0.81 (95% CI: 0.76–0.86) in internal and external validation sets, respectively. CpGs at progesterone receptor binding sites hypomethylated in normal breast tissue of women with breast cancer or in BRCA mutation carriers are also hypomethylated in cervical samples of women with poor prognostic breast cancer. Our data indicate that a systemic epigenetic programming defect is highly prevalent in women who develop breast cancer. Further studies validating the WID-BC-index may enable clinical implementation for monitoring breast cancer risk.en_US
dc.language.isoengen_US
dc.publisherNatureen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleThe WID-BC-index identifies women with primary poor prognostic breast cancer based on DNA methylation in cervical samplesen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.source.articlenumber449en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2
dc.identifier.doi10.1038/s41467-021-27918-w
dc.identifier.cristin2025643
dc.source.journalNature Communicationsen_US
dc.identifier.citationNature Communications. 2022, 13, 449.en_US
dc.source.volume13en_US


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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal