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dc.contributor.authorBarrett, James E.
dc.contributor.authorJones, Allison
dc.contributor.authorEvans, Iona
dc.contributor.authorReisel, Daniel
dc.contributor.authorHerzog, Chiara
dc.contributor.authorChindera, Kantaraja
dc.contributor.authorKristiansen, Mark
dc.contributor.authorLeavy, Olivia C.
dc.contributor.authorManchanda, Ranjit
dc.contributor.authorBjørge, Line
dc.contributor.authorZikan, Michal
dc.contributor.authorCibula, David
dc.contributor.authorWidschwendter, Martin
dc.date.accessioned2022-10-10T12:13:09Z
dc.date.available2022-10-10T12:13:09Z
dc.date.created2022-05-19T13:36:46Z
dc.date.issued2022
dc.identifier.issn2041-1723
dc.identifier.urihttps://hdl.handle.net/11250/3025114
dc.description.abstractThe vast majority of epithelial ovarian cancer arises from tissues that are embryologically derived from the Müllerian Duct. Here, we demonstrate that a DNA methylation signature in easy-to-access Müllerian Duct-derived cervical cells from women with and without ovarian cancer (i.e. referred to as the Women’s risk IDentification for Ovarian Cancer index or WID-OC-index) is capable of identifying women with an ovarian cancer in the absence of tumour DNA with an AUC of 0.76 and women with an endometrial cancer with an AUC of 0.81. This and the observation that the cervical cell WID-OC-index mimics the epigenetic program of those cells at risk of becoming cancerous in BRCA1/2 germline mutation carriers (i.e. mammary epithelium, fallopian tube fimbriae, prostate) further suggest that the epigenetic misprogramming of cervical cells is an indicator for cancer predisposition. This concept has the potential to advance the field of risk-stratified cancer screening and prevention.en_US
dc.language.isoengen_US
dc.publisherNatureen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleThe DNA methylome of cervical cells can predict the presence of ovarian canceren_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.source.articlenumber448en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2
dc.identifier.doi10.1038/s41467-021-26615-y
dc.identifier.cristin2025651
dc.source.journalNature Communicationsen_US
dc.identifier.citationNature Communications. 2022, 13, 448.en_US
dc.source.volume13en_US


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