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dc.contributor.authorTrøseid, Marius
dc.contributor.authorDahl, Tuva Børresdatter
dc.contributor.authorHolter, Jan Cato
dc.contributor.authorKildal, Anders Benjamin
dc.contributor.authorMurphy, Sarah Louise Mikalsen
dc.contributor.authorYang, Kuan
dc.contributor.authorQuiles Jimenez, Ana Maria Teresa
dc.contributor.authorHeggelund, Lars
dc.contributor.authorMuller, Karl Erik
dc.contributor.authorTveita, Anders Aune
dc.contributor.authorMichelsen, Annika Elisabet
dc.contributor.authorBøe, Simen
dc.contributor.authorHolten, Aleksander Rygh
dc.contributor.authorHoel, Hedda Benedicte
dc.contributor.authorMathiessen, Alexander
dc.contributor.authorAaløkken, Trond Mogens
dc.contributor.authorFevang, Børre
dc.contributor.authorGranerud, Beathe Kiland
dc.contributor.authorTonby, Kristian
dc.contributor.authorNezvalova-Henriksen, Katerina
dc.contributor.authorLerum, Tøri Vigeland
dc.contributor.authorMüller, Fredrik
dc.contributor.authorSkjønsberg, Ole Henning
dc.contributor.authorBarratt-Due, Andreas
dc.contributor.authorRiise, Anne Margarita Dyrhol
dc.contributor.authorAukrust, Pål
dc.contributor.authorHalvorsen, Bente Evy
dc.contributor.authorUeland, Thor
dc.description.abstractBackground: T-cell activation is associated with an adverse outcome in COVID-19, but whether T-cell activation and exhaustion relate to persistent respiratory dysfunction and death is unknown. Objectives: To investigate whether T-cell activation and exhaustion persist and are associated with prolonged respiratory dysfunction and death after hospitalization for COVID-19. Methods: Plasma and serum from two Norwegian cohorts of hospitalized patients with COVID-19 (n = 414) were analyzed for soluble (s) markers of T-cell activation (sCD25) and exhaustion (sTim-3) during hospitalization and follow-up. Results: Both markers were strongly associated with acute respiratory failure, but only sTim-3 was independently associated with 60-day mortality. Levels of sTim-3 remained elevated 3 and 12 months after hospitalization and were associated with pulmonary radiological pathology after 3 months. Conclusion: Our findings suggest prolonged T-cell exhaustion is an important immunological sequela, potentially related to long-term outcomes after severe COVID-19.en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.titlePersistent T-cell exhaustion in relation to prolonged pulmonary pathology and death after severe COVID-19: Results from two Norwegian cohort studiesen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holderCopyright 2022 the authorsen_US
dc.source.journalJournal of Internal Medicineen_US
dc.identifier.citationJournal of Internal Medicine. 2022, 292 (5), 816-828.en_US

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Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal