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dc.contributor.authorSkjellerudsveen, Berit Mære
dc.contributor.authorOmdal, Roald
dc.contributor.authorHetta, Anne Kristine
dc.contributor.authorKvaløy, Jan Terje
dc.contributor.authorAabakken, Lars
dc.contributor.authorSkoie, Inger Marie
dc.contributor.authorGrimstad, Tore Bjørn
dc.date.accessioned2022-10-25T11:02:14Z
dc.date.available2022-10-25T11:02:14Z
dc.date.created2022-10-11T08:27:52Z
dc.date.issued2022
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/11250/3028170
dc.description.abstractFatigue is increasingly recognized as a major complaint in patients with chronic inflammatory and autoimmune diseases. Although fatigue is assumed to represent a significant problem in celiac disease, existing knowledge is scarce, and opinions are conflicting. This study aimed to investigate the prevalence and severity of fatigue in patients with newly diagnosed celiac disease and compare it with healthy control subjects. Ninety patients with newly diagnosed celiac disease were compared with 90 age- and sex-matched healthy subjects. The primary endpoints were fatigue severity as measured by: the fatigue Visual Analog Scale (fVAS), the Fatigue Severity Scale (FSS), and the inverted Vitality subscale of the MOS36 (SF-36vs). Higher scores indicate more severe fatigue. Clinically relevant fatigue was determined using predefined cut-off values. Secondary endpoints were the associations between fatigue, and sex, age, depression, pain, and selected biochemical variables. The median (IQR) fVAS-scores were 43.0 (18.0–64.5) in patients, and 9.0 (2.0–16.0) in the control group (p < 0.001); and the FSS scores 3.8 (2.0–4.8) in patients, and 1.4 (1.0–1.9) in control subjects (p < 0.001). Inverted SF-36vs scores had a mean (SD) value of 58.8 (23.6) in patients, and 29.7 (14.3) in healthy subjects (p < 0.001). The presence of clinically relevant fatigue ranged from 41 to 50% in patients. Increased fatigue severity was associated with female sex, younger age, and elevated pain and depression scores, but not with levels of selected biochemical variables, including hemoglobin. Fatigue is a severe and frequent phenomenon in patients with untreated celiac disease.en_US
dc.language.isoengen_US
dc.publisherNatureen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleFatigue: a frequent and biologically based phenomenon in newly diagnosed celiac diseaseen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.source.articlenumber7281en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.doi10.1038/s41598-022-11802-8
dc.identifier.cristin2060283
dc.source.journalScientific Reportsen_US
dc.identifier.citationScientific Reports. 2022, 12, 7281.en_US
dc.source.volume12en_US


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