dc.contributor.author | Sommersten, Cathrine Horn | |
dc.contributor.author | Laupsa-Borge, Johnny | |
dc.contributor.author | Andersen, Amanda Iselin Olesen | |
dc.contributor.author | Fasmer, Kristine Eldevik | |
dc.contributor.author | Holmefjord, Mari-Anna Frydenlund | |
dc.contributor.author | Revheim, Ingrid | |
dc.contributor.author | Johannessen, Kristine Kjerpeseth | |
dc.contributor.author | Næsheim, Nicole Tandrevold | |
dc.contributor.author | Storås, Inghild | |
dc.contributor.author | Leikanger, Trine | |
dc.contributor.author | Amundsen, Kristin | |
dc.contributor.author | Skjerve, Karoline Lyngstad | |
dc.contributor.author | Lawrence-Archer, Laurence | |
dc.contributor.author | Spjelkavik, Camilla | |
dc.contributor.author | Haldorsen, Ingfrid S. | |
dc.contributor.author | Lindseth, Inge Andreas | |
dc.contributor.author | Dierkes, Jutta | |
dc.contributor.author | Mellgren, Gunnar | |
dc.contributor.author | Dankel, Simon N | |
dc.date.accessioned | 2022-10-28T11:37:10Z | |
dc.date.available | 2022-10-28T11:37:10Z | |
dc.date.created | 2022-10-24T13:36:20Z | |
dc.date.issued | 2022 | |
dc.identifier.issn | 0261-5614 | |
dc.identifier.uri | https://hdl.handle.net/11250/3028850 | |
dc.description.abstract | Background & aims: Visceral adipose tissue (VAT) volume is associated with common lifestyle diseases. Dietary quality, including food matrix and degree of carbohydrate cellularity, as well as the carbohydrate/fat ratio, may influence VAT volume. We aimed to determine the effects of isocaloric diets differing in either “cellularity”, a novel marker of dietary carbohydrate quality, or carbohydrate amount on visceral fat volume and anthropometric measures in adults with obesity.
Methods: In a randomized controlled trial of 193 people with obesity/central adiposity, we compared changes in VAT volume after 6 and 12 months, measured by abdominal computed tomography, on three isocaloric eating patterns based on “acellular” carbohydrate sources (e.g., flour-based whole-grain products; comparator arm), “cellular” carbohydrate sources (minimally processed foods with intact cellular structures such as fruits, potatoes/tubers, and rice), or low-carbohydrate high-fat (LCHF) principles. Outcomes were compared by an intention-to-treat (ITT) analysis using constrained linear mixed-effects modelling (cLMM) providing baseline-adjusted change scores and proper missing data handling without imputation.
Results: 78 and 57 participants completed 6 and 12 months, respectively, with similar intakes of energy (females: 1820−2060 kcal, males: 2480−2550 kcal) and protein (16–17 energy percent, E%) throughout the intervention, and only modest reductions in energy from baseline. Reported dietary intakes were 42–44, 41–42, and 11–15 E% carbohydrate and 36–38, 37–38, and 66–70 E% fat in the acellular, cellular and LCHF groups, respectively. There were no significant between-group differences in VAT volume after 6 months (cellular vs. acellular [95% CI]: −55 cm³ [−545, 436]; LCHF vs. acellular [95% CI]: −225 cm³ [−703, 253]) or after 12 months (cellular vs. acellular [95% CI]: −122 cm³ [−757, 514]; LCHF vs. acellular [95% CI]: −317 cm³ [−943, 309]). VAT volume decreased significantly within all groups by 14–18% and 12–17% after 6 and 12 months, respectively. Waist circumference was reduced to a significantly greater degree in the LCHF vs. acellular group at 6 months (LCHF vs. acellular [95% CI]: −2.78 cm [−5.54, −0.017]).
Conclusions: Despite modest energy restriction, the three isocaloric eating patterns, differing in carbohydrate cellularity and amount, decreased visceral fat volume significantly and to a similar clinically relevant degree. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Diets differing in carbohydrate cellularity and amount similarly reduced visceral fat in people with obesity - a randomized controlled trial (CARBFUNC) | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2022 The Author(s) | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.doi | 10.1016/j.clnu.2022.08.028 | |
dc.identifier.cristin | 2064437 | |
dc.source.journal | Clinical Nutrition | en_US |
dc.source.pagenumber | 2345-2355 | en_US |
dc.identifier.citation | Clinical Nutrition. 2022, 41 (10), 2345-2355. | en_US |
dc.source.volume | 41 | en_US |
dc.source.issue | 10 | en_US |