dc.contributor.author | Tahseen, Sabira | |
dc.contributor.author | Ambreen, Atiqa | |
dc.contributor.author | Ishtiaq, Sheeba | |
dc.contributor.author | Khanzada, Faisal M. | |
dc.contributor.author | Safdar, Nauman | |
dc.contributor.author | Sviland, Lisbet | |
dc.contributor.author | Mustafa, Tehmina | |
dc.date.accessioned | 2022-12-01T12:34:24Z | |
dc.date.available | 2022-12-01T12:34:24Z | |
dc.date.created | 2022-08-30T12:55:52Z | |
dc.date.issued | 2022 | |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | https://hdl.handle.net/11250/3035360 | |
dc.description.abstract | Extrapulmonary tuberculosis often poses a diagnostic challenge. This study aimed to assess the value of histological examination in diagnosing tuberculous lymphadenitis (LNTB) when performed simultaneously with rapid molecular assay (Xpert MTB/RIF) testing. People presumed to have LNTB were prospectively enrolled in a tertiary care hospital. Excision biopsy was performed and tested by histology, Xpert, and culture. Of 390 lymph nodes, 11 (2.8%) were positive by AFB microscopy, 124 (31.8%) by Xpert, 137 (35.1%) by culture, and histopathology was consistent with TB in 208 (53.3%). Altogether, LNTB was diagnosed in 228 and bacteriologically confirmed TB in 178 cases. Against culture, histopathology versus Xpert had higher sensitivity (93 vs. 62%) but lower specificity (68 vs. 83%). In patients with short clinical history, a significantly higher number of Xpert-positive specimens were culture-positive. Among patients with histology suggestive of TB, no difference was seen in response to treatment between bacteriology positive and negative, but a significant slow response was noted in bacteriology confirmed TB with nonspecific histology. In a country like Pakistan, with high TB and low HIV prevalence, diagnosis is possible for more than 95% of LNTB when Xpert and histopathology examination is used in combination, compared to less than 60% by Xpert alone. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Springer Nature | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | The value of histological examination in the diagnosis of tuberculous lymphadenitis in the era of rapid molecular diagnosis | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2022 the authors | en_US |
dc.source.articlenumber | 8949 | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.doi | 10.1038/s41598-022-12660-0 | |
dc.identifier.cristin | 2047189 | |
dc.source.journal | Scientific Reports | en_US |
dc.identifier.citation | Scientific Reports. 2022, 12, 8949. | en_US |
dc.source.volume | 12 | en_US |