dc.contributor.author | Satrell, Emma Elsa Carolina | |
dc.contributor.author | Clemm, Hege Synnøve Havstad | |
dc.contributor.author | Røksund, Ola Drange | |
dc.contributor.author | Hufthammer, Karl Ove | |
dc.contributor.author | Thorsen, Einar | |
dc.contributor.author | Halvorsen, Thomas | |
dc.contributor.author | Vollsæter, Maria | |
dc.date.accessioned | 2022-12-07T08:09:51Z | |
dc.date.available | 2022-12-07T08:09:51Z | |
dc.date.created | 2022-01-31T12:36:05Z | |
dc.date.issued | 2022 | |
dc.identifier.issn | 0903-1936 | |
dc.identifier.uri | https://hdl.handle.net/11250/3036240 | |
dc.description.abstract | Background: Gas exchange in extremely preterm (EP) infants must take place in fetal lungs. Childhood lung diffusing capacity of the lung for carbon monoxide (DLCO) is reduced; however, longitudinal development has not been investigated. We describe the growth of DLCO and its subcomponents to adulthood in EP compared with term-born subjects.
Methods: Two area-based cohorts born at gestational age ≤28 weeks or birthweight ≤1000 g in 1982–1985 (n=48) and 1991–1992 (n=35) were examined twice, at ages 18 and 25 years and 10 and 18 years, respectively, and compared with matched term-born controls. Single-breath DLCO was measured at two oxygen pressures, with subcomponents (membrane diffusion (DM) and pulmonary capillary blood volume (VC)) calculated using the Roughton–Forster equation.
Results: Age-, sex- and height-standardised transfer coefficients for carbon monoxide (KCO) and DLCO were reduced in EP compared with term-born subjects, and remained so during puberty and early adulthood (p-values for all time-points and both cohorts ≤0.04), whereas alveolar volume (VA) was similar. Development occurred in parallel to term-born controls, with no signs of pubertal catch-up growth nor decline at age 25 years (p-values for lack of parallelism within cohorts 0.99, 0.65, 0.71, 0.94 and 0.44 for z-DLCO, z-VA, z-KCO, DM and VC, respectively). Split by membrane and blood volume components, findings were less clear; however, membrane diffusion seemed most affected.
Conclusions: Pulmonary diffusing capacity was reduced in EP compared with term-born subjects, and development from childhood to adulthood tracked in parallel to term-born subjects, with no signs of catch-up growth nor decline at age 25 years. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | European Respiratory Society | en_US |
dc.title | Development of lung diffusion to adulthood following extremely preterm birth | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2022 the authors | en_US |
dc.source.articlenumber | 2004103 | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.doi | 10.1183/13993003.04103-2020 | |
dc.identifier.cristin | 1994614 | |
dc.source.journal | European Respiratory Journal | en_US |
dc.identifier.citation | European Respiratory Journal. 2022, 59 (5), 2004103. | en_US |
dc.source.volume | 59 | en_US |
dc.source.issue | 5 | en_US |