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dc.contributor.authorPlöntzke, Julia
dc.contributor.authorBerg, Mascha
dc.contributor.authorEhrig, Rainald
dc.contributor.authorLeonhard-Marek, Sabine
dc.contributor.authorMüller, Kerstin Elisabeth
dc.contributor.authorRöblitz, Susanna
dc.date.accessioned2022-12-08T08:07:07Z
dc.date.available2022-12-08T08:07:07Z
dc.date.created2022-11-18T08:29:16Z
dc.date.issued2022
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/11250/3036632
dc.description.abstractHypokalemia in dairy cows, which is characterized by too low serum potassium levels, is a severe mineral disorder that can be life threatening. In this paper, we explore different originating conditions of hypokalemia—reduced potassium intake, increased excretion, acid-base disturbances, and increased insulin—by using a dynamic mathematical model for potassium balance in non-lactating and lactating cows. The simulations confirm observations described in literature. They illustrate, for example, that changes in dietary intake or excretion highly effect intracellular potassium levels, whereas extracellular levels vary only slightly. Simulations also show that the higher the potassium content in the diet, the more potassium is excreted with urine. Application of the mathematical model assists in experimental planning and therefore contributes to the 3R strategy: reduction, refinement and replacement of animal experiments.en_US
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleModel-based exploration of hypokalemia in dairy cowsen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2022 the authorsen_US
dc.source.articlenumber19781en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.doi10.1038/s41598-022-22596-0
dc.identifier.cristin2076017
dc.source.journalScientific Reportsen_US
dc.identifier.citationScientific Reports. 2022, 12, 19781.en_US
dc.source.volume12en_US


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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal