Survival after aortic root replacement with a stentless xenograft is determined by patient characteristics
dc.contributor.author | Dagnegård, Hanna H. | |
dc.contributor.author | Bekke, Kirstine | |
dc.contributor.author | Kolseth, Solveig Moss | |
dc.contributor.author | Glaser, Natalie | |
dc.contributor.author | Wallén, Christoffer | |
dc.contributor.author | El-Hamamsy, Ismail | |
dc.contributor.author | Vidisson, Kristjan O. | |
dc.contributor.author | Lie, Asbjørn Sigstad | |
dc.contributor.author | Valentin, Jan | |
dc.contributor.author | Sartipy, Ulrik | |
dc.contributor.author | Haaverstad, Rune | |
dc.contributor.author | Vanky, Farkas | |
dc.contributor.author | Lefebvre, Laurence | |
dc.contributor.author | Gudbjartsson, Tomas | |
dc.contributor.author | Johnsen, Søren P. | |
dc.contributor.author | Søndergaard, Lars | |
dc.contributor.author | Thyregod, Gustav H. | |
dc.contributor.author | Lund, Jens T. | |
dc.contributor.author | Ihlemann, Nikolaj | |
dc.contributor.author | Smerup, Morten H. | |
dc.date.accessioned | 2022-12-20T14:07:32Z | |
dc.date.available | 2022-12-20T14:07:32Z | |
dc.date.created | 2022-02-20T14:49:07Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 0022-5223 | |
dc.identifier.uri | https://hdl.handle.net/11250/3038892 | |
dc.description.abstract | Objectives Our objective was to examine intermediate-term survival and reinterventions in unselected patients, stratified according to indication, who received a Freestyle (Medtronic Inc, Minneapolis, Minn) bioprosthesis as a full aortic root replacement. Methods Data from medical records were retrospectively collected for patients who had aortic root replacement using Freestyle bioprostheses between 1999 and 2018 at 6 North-Atlantic centers. Survival status was extracted from national registries and results stratified according to indication for surgery. Results We included 1030 implantations in 1008 patients with elective indications for surgery: aneurysm (39.8%), small root (8.3%), and other (13.8%), and urgent/emergent indications: endocarditis (26.7%) and Stanford type A aortic dissection (11.4%). Across indications, 46.3% were nonelective cases and 34.0% were reoperations. Median age was 66.0 (interquartile range, 58.0-71.8) years and median follow-up was 5.0 (interquartile range, 2.6-7.9) years. Thirty-day mortality varied from 2.9% to 27.4% depending on indication. Intermediate survival for 90-day survivors with elective indications were not different from the general population standardized for age and sex (P = .95, .83, and .16 for aneurysms, small roots, and other, respectively). In contrast, patients with endocarditis and type A dissection had excess mortality (P < .001). Freedom from valve reinterventions was 95.0% and 94.4% at 5 and 8 years, respectively. In all, 52 patients (5.2%) underwent reinterventions, most because of endocarditis. Conclusions At intermediate term follow-up this retrospective study provides further support for the use of the Freestyle bioprosthesis in the real-world setting of diverse, complex, and often high-risk aortic root replacement and suggests that outcome is determined by patient and disease, rather than by prosthesis, characteristics. | en_US |
dc.language.iso | eng | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Survival after aortic root replacement with a stentless xenograft is determined by patient characteristics | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2021 The Author(s) | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.doi | 10.1016/j.jtcvs.2021.07.011 | |
dc.identifier.cristin | 2003784 | |
dc.source.journal | Journal of Thoracic and Cardiovascular Surgery | en_US |
dc.source.pagenumber | 1712-1724.e10 | en_US |
dc.identifier.citation | Journal of Thoracic and Cardiovascular Surgery. 2022, 164 (6), 1712-1724.e10. | en_US |
dc.source.volume | 164 | en_US |
dc.source.issue | 6 | en_US |
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