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dc.contributor.authorMamasoula, Chrysovalanto
dc.contributor.authorAddor, Marie-Claude
dc.contributor.authorCarbonell, Clara Cavero
dc.contributor.authorDias, Carlos M.
dc.contributor.authorEchevarría-González-de-Garibay, Luis-Javier
dc.contributor.authorGatt, Miriam
dc.contributor.authorKhoshnood, Babak
dc.contributor.authorKlungsøyr, Kari
dc.contributor.authorRandall, Kay
dc.contributor.authorStoianova, Sylvia
dc.contributor.authorHaeusler, Martin
dc.contributor.authorNelen, Vera
dc.contributor.authorNeville, Amanda J.
dc.contributor.authorPerthus, Isabelle
dc.contributor.authorPierini, Anna
dc.contributor.authorBertaut-Nativel, Bénédicte
dc.contributor.authorRissmann, Anke
dc.contributor.authorRouget, Florence
dc.contributor.authorSchaub, Bruno
dc.contributor.authorTucker, David
dc.contributor.authorWellesley, Diana
dc.contributor.authorZymak-Zakutnia, Natalya
dc.contributor.authorBarisic, Ingeborg
dc.contributor.authorde Walle, Hermien E.K.
dc.contributor.authorLanzoni, Monica
dc.contributor.authorMullaney, Carmel
dc.contributor.authorPennington, Lindsay
dc.contributor.authorRankin, Judith
dc.description.abstractBackground The total prevalence of congenital heart defects (CHDs) varies by populations and over time. Studies that examine trends in the prevalence of CHD in different regions may shed light on our understanding of the occurrence of CHD and the impact of different risk factors. Objectives To examine trends in total and live birth prevalence of nonsyndromic CHD in Europe between the years 2008 and 2015 and to investigate if the decreasing trend reported by previous studies is continuing. Methods Cases of CHD delivered between January 1, 2008 and December 31, 2015 notified to 25 population-based EUROCAT (European Surveillance of Congenital Anomalies) registries in 14 countries, formed the population-based case-series. Prevalence (total/live) rates and 95% confidence intervals were calculated as the number of cases per 10,000 births (live and stillbirths). Time trends in prevalence of all nonsyndromic CHDs and for three CHD severity groups (very severe, severe, and less severe) were plotted using a Poisson regression multilevel approach. Results The total prevalence of nonsyndromic CHD was 57.1 per 10,000 births (live births and stillbirths) for the 8-year period and remained stable across the three CHD severity groups while the live birth prevalence was 60.2 per 10,000 births. There was considerable variation in the reported total CHD prevalence and the direction of trends by registry. A decreasing prevalence of CHD was observed for the Norway and England/Wales registries, whereas the CHD prevalence increased for registries in Italy and Croatia. Conclusions The total prevalence of CHD in Europe between the years 2008 and 2015 remained stable for all CHD and across the three CHD severity groups. The decreasing trend reported by previous studies has not continued. However, we found significant differences in the total and live birth prevalence by registry.en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.titlePrevalence of congenital heart defects in Europe, 2008–2015: A registry-based studyen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.source.journalBirth Defects Researchen_US
dc.identifier.citationBirth Defects Research. 2022, 114 (20), 1404-1416.en_US

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Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
Med mindre annet er angitt, så er denne innførselen lisensiert som Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal