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dc.contributor.authorSeyedAlinaghi, SeyedAhmad
dc.contributor.authorKarimi, Amirali
dc.contributor.authorMirzapour, Pegah
dc.contributor.authorAfroughi, Fatemeh
dc.contributor.authorNoroozi, Alireza
dc.contributor.authorArjmand, Ghazal
dc.contributor.authorAbshenas, Shayan
dc.contributor.authorPashaei, Zahra
dc.contributor.authorTantuoyir, Marcarious M.
dc.contributor.authorDadras, Omid
dc.contributor.authorQaderi, Kowsar
dc.contributor.authorSaeidi, Solmaz
dc.contributor.authorDehghani, Soheil
dc.contributor.authorShabanzadeh Pirsaraie, Ayda
dc.contributor.authorMehraeen, Esmaeil
dc.contributor.authorAfsahi, Amir Masoud
dc.date.accessioned2022-12-30T13:55:04Z
dc.date.available2022-12-30T13:55:04Z
dc.date.created2022-12-16T13:42:52Z
dc.date.issued2022
dc.identifier.issn2398-8835
dc.identifier.urihttps://hdl.handle.net/11250/3040109
dc.description.abstractIntroduction: C-reactive protein (CRP) and cytokines levels could alter in patients with coronavirus disease (COVID-19) due to the inflammatory response caused by the virus. This analysis aimed to assess the relationship between the CRP levels and the levels of various cytokines in COVID-19 patients. Materials and Methods: We searched the databases of PubMed, Cochrane, and Web of Science for relevant articles on May 29th, 2021. Applying the inclusion/exclusion criteria, the retrieved records underwent two-phase screenings; first, a title/abstract screening process, and then, a full-text screening to find the eligible studies. Data for study variables were extracted, including the CRP levels and the levels of all reported cytokines. A strong and significant relationship between Interleukins and CRP was defined as: p ≤ 0.05, 0.7 ≤ r ≤ 1. Results: In this study, 103 studies were included for systematic review and correlation analysis. The aggregate mean and SD of study variables were calculated and reported. The correlation between Interleukins and CRP was measured using correlation coefficient (r). It appeared that interleukin (IL)-10 has a moderate and significant relationship with CRP (p ≤ 0.05, r = 0.472). IL-10 predicted almost 10% of CRP changes. Conclusion: This correlation analysis suggests IL-10 is moderately correlated with CRP levels in patients with COVID-19 infection. A better understanding of the pro-inflammatory markers could contribute to the implementation of therapeutic and preventive approaches. More prospective studies are suggested to explore the relationship between CRP and cytokines as potential markers for the early identification of COVID-19 progression and severity.en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleThe relationship between C-reactive protein and levels of various cytokines in patients with COVID-19: A systematic review and correlation analysisen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2022 the authorsen_US
dc.source.articlenumbere868en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.doi10.1002/hsr2.868
dc.identifier.cristin2094410
dc.source.journalHealth Science Reportsen_US
dc.identifier.citationHealth Science Reports. 2022, 5 (6), e868.en_US
dc.source.volume5en_US
dc.source.issue6en_US


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