dc.contributor.author | Aune, Arleen | |
dc.contributor.author | Gerdts, Eva | |
dc.contributor.author | Kokorina, Marina Victorovna | |
dc.contributor.author | Kringeland, Ester Anne | |
dc.contributor.author | Midtbø, Helga Bergljot | |
dc.contributor.author | Løvås, Kristian | |
dc.contributor.author | Grytaas, Marianne | |
dc.date.accessioned | 2023-01-02T08:41:56Z | |
dc.date.available | 2023-01-02T08:41:56Z | |
dc.date.created | 2022-09-21T08:27:23Z | |
dc.date.issued | 2022 | |
dc.identifier.issn | 0263-6352 | |
dc.identifier.uri | https://hdl.handle.net/11250/3040196 | |
dc.description.abstract | Objective: We compared persistent cardiac organ damage in patients treated surgically or medically for primary aldosteronism.
Methods: Eighty-four patients (age 57 ± 11 years, 27% women) with primary aldosteronism underwent echocardiography at time of diagnosis and after one year of treatment (49% adrenalectomy, 51% medical treatment). Persistent cardiac organ damage was defined as presence of left ventricle (LV) hypertrophy, low LV midwall shortening, global longitudinal strain and/or enlarged left atrium both at baseline and at follow-up.
Results: At one year, a significant regression of LV hypertrophy was observed in surgically (44 vs. 22%, P= 0.039), but not in medically treated patients (60 vs. 51%, P = 0.206). The prevalence of enlarged left atrium was reduced in both groups (both P < 0.001), whereas systolic myocardial function remained unchanged. In multivariable logistic regression analysis, medical treatment [odds ratio (OR) 4.88 (95% confidence interval (CI) 1.26–18.88)] was a strong predictor of persistent LV hypertrophy independent of higher BMI [OR 1.20 (95% CI 1.04–1.38)] and presence of diabetes [OR 6.48 (95% CI 1.20–34.83), all P < 0.05]. Persistently low midwall shortening was associated with suppressed plasma renin after one year [OR 6.11 (95% CI 1.39–26.7)] and lower renal function [OR 0.96 (95% CI 0.94–0.99), both P < 0.05]. The strongest predictor of persistently low global longitudinal strain was higher HbA1c [OR 2.37 (95% CI 1.12–5.02), P = 0.024].
Conclusion: Persistent cardiac organ damage was more common in the medical treatment group and associated with incomplete aldosterone blockade, impaired renal function and presence of metabolic comorbidities. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Wolters Kluwer | en_US |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.no | * |
dc.title | Persistent cardiac organ damage in surgically and medically treated primary aldosteronism | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2022 The Author(s) | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.doi | 10.1097/HJH.0000000000003135 | |
dc.identifier.cristin | 2053725 | |
dc.source.journal | Journal of Hypertension | en_US |
dc.source.pagenumber | 1204-1211 | en_US |
dc.identifier.citation | Journal of Hypertension. 2022, 40 (6), 1204-1211. | en_US |
dc.source.volume | 40 | en_US |
dc.source.issue | 6 | en_US |