dc.contributor.author | Sivertsen, Audun | |
dc.contributor.author | Dyrhovden, Ruben | |
dc.contributor.author | Tellevik, Marit Gjerde | |
dc.contributor.author | Bruvold, Torbjørn Sæle | |
dc.contributor.author | Nybakken, Eirik Jovall | |
dc.contributor.author | Skutlaberg, Dag Harald | |
dc.contributor.author | Skarstein, Ingerid | |
dc.contributor.author | Kommedal, Øyvind | |
dc.date.accessioned | 2023-01-02T12:17:33Z | |
dc.date.available | 2023-01-02T12:17:33Z | |
dc.date.created | 2022-10-10T12:20:32Z | |
dc.date.issued | 2022 | |
dc.identifier.issn | 2165-0497 | |
dc.identifier.uri | https://hdl.handle.net/11250/3040289 | |
dc.description.abstract | We hereby present the first descriptions of human-invasive infections caused by Escherichia marmotae, a recently described species that encompasses the former “Escherichia cryptic clade V.” We describe four cases, one acute sepsis of unknown origin, one postoperative sepsis after cholecystectomy, one spondylodiscitis, and one upper urinary tract infection. Cases were identified through unsystematic queries in a single clinical lab over 6 months. Through genome sequencing of the causative strains combined with available genomes from elsewhere, we demonstrate Es. marmotae to be a likely ubiquitous species containing genotypic virulence traits associated with Escherichia pathogenicity. The invasive isolates were scattered among isolates from a range of nonhuman sources in the phylogenetic analyses, thus indicating inherent virulence in multiple lineages. Pan genome analyses indicate that Es. marmotae has a large accessory genome and is likely to obtain ecologically advantageous traits, such as genes encoding antimicrobial resistance. Reliable identification might be possible by matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS), but relevant spectra are missing in commercial databases. It can be identified through 16S rRNA gene sequencing. Escherichia marmotae could represent a relatively common human pathogen, and improved diagnostics will provide a better understanding of its clinical importance. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | ASM | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Escherichia marmotae—a Human Pathogen Easily Misidentified as Escherichia coli | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2022 The Author(s) | en_US |
dc.source.articlenumber | e02035-21 | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.doi | 10.1128/spectrum.02035-21 | |
dc.identifier.cristin | 2060029 | |
dc.source.journal | Microbiology spectrum | en_US |
dc.identifier.citation | Microbiology spectrum. 2022, 10 (2), e02035-21. | en_US |
dc.source.volume | 10 | en_US |
dc.source.issue | 2 | en_US |