dc.contributor.author | Hov, Brit | |
dc.contributor.author | Andersen, Tiina Maarit | |
dc.contributor.author | Hovland, Vegard | |
dc.contributor.author | Toussaint, Michel | |
dc.date.accessioned | 2023-04-04T11:51:24Z | |
dc.date.available | 2023-04-04T11:51:24Z | |
dc.date.created | 2018-09-15T17:39:34Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 1526-0542 | |
dc.identifier.uri | https://hdl.handle.net/11250/3062093 | |
dc.description.abstract | Mechanical insufflation-exsufflation (MI-E) is a strategy to treat pulmonary exacerbations in neuromuscular disorders (NMDs). Pediatric guidelines for optimal setting titration of MI-E are lacking and the settings used in studies vary. Our objective was to assess the actual MI-E settings being used in current clinical treatment of children with NMDs and a survey was sent in July 2016 to European expertise centers. Ten centers from seven countries gave information on MI-E settings for 240 children aged 4 months to 17.8 years (mean 10.5). Settings varied greatly between the centers. Auto mode was used in 71%, triggering of insufflation in 21% and manual mode in 8% of the cases. Mean (SD) time for insufflation (Ti) and exsufflation (Te) were 1.9 (0.5) and 1.8 (0.6) s respectively, both ranging from 1 to 4 s. Asymmetric time settings were common (65%). Mean (SD) insufflation (Pi) and exsufflation (Pe) pressures were 32.4 (7.8) and −36.9 (7.4), ranging 10 to 50 and −10 to −60 cmH2O, respectively. Asymmetric pressures were as common as symmetric. Both Ti, Te, Pi and Pe increased with age (p < 0.001). In conclusion, pediatric MI-E settings in clinical use varied greatly and altered with age, highlighting the need of more studies to improve our knowledge of optimal settings in MI-E in children with NMDs. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.no | * |
dc.title | The clinical use of mechanical insufflation-exsufflation in children with neuromuscular disorders in Europe | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2017 The Author(s) | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.doi | 10.1016/j.prrv.2017.08.003 | |
dc.identifier.cristin | 1609820 | |
dc.source.journal | Paediatric Respiratory Reviews | en_US |
dc.source.pagenumber | 69-73 | en_US |
dc.identifier.citation | Paediatric Respiratory Reviews. 2018, 27, 69-73. | en_US |
dc.source.volume | 27 | en_US |