Do Poor Diet and Lifestyle Behaviors Modify the Genetic Susceptibility to Impulsivity in the General Population?
dc.contributor.author | Xie, Tian | |
dc.contributor.author | Schweren, Lizanne J.S. | |
dc.contributor.author | Larsson, Henrik | |
dc.contributor.author | Li, Lin | |
dc.contributor.author | Rietz, Ebba Du | |
dc.contributor.author | Haavik, Jan | |
dc.contributor.author | Kvalvik, Liv Grimstvedt | |
dc.contributor.author | Solberg, Berit Skretting | |
dc.contributor.author | Klungsøyr, Kari | |
dc.contributor.author | Snieder, Harold | |
dc.contributor.author | Hartman, Catharina A. | |
dc.date.accessioned | 2023-05-03T06:44:09Z | |
dc.date.available | 2023-05-03T06:44:09Z | |
dc.date.created | 2023-05-02T10:36:11Z | |
dc.date.issued | 2023-03-27 | |
dc.identifier.issn | 2072-6643 | |
dc.identifier.uri | https://hdl.handle.net/11250/3065875 | |
dc.description.abstract | The present study investigated whether an unhealthy diet and other lifestyle behaviors may modify the genetic susceptibility to impulsivity. A total of 33,047 participants (mean age = 42.1 years, 59.8% females) from the Dutch Lifelines cohort were included. Each diet index and other lifestyle behaviors were tested for their interactions on the effect on the attention-deficit/hyperactivity disorder (ADHD) polygenic risk score (PRS) on impulsivity using a linear regression model with adjustment for covariates. The ADHD PRS was significantly associated with impulsivity (B = 0.03 (95% CI: 0.02, 0.04); p = 2.61 × 10−9). A poorer diet, a higher intake of energy, and a higher intake of fat were all associated with higher impulsivity, and a high intake of energy amplified the effect of ADHD PRS on impulsivity (e.g., for the interaction term of ADHD PRS and highest tertile on intake of energy, B = 0.038 (95% CI: 0.014, 0.062); p = 0.002. The other lifestyle factors, namely short and long sleep duration, current and past smoking, higher alcohol intake, and more time spent on moderate-to-vigorous physical activity were associated with higher impulsivity, but no interaction effect was observed. In conclusion, we found that a high intake of energy exacerbated the genetic susceptibility to impulsivity. Our study helps to improve our understanding of the role of diet and genetic factors on impulsivity. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | MDPI | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Do Poor Diet and Lifestyle Behaviors Modify the Genetic Susceptibility to Impulsivity in the General Population? | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2023 the authors | en_US |
dc.source.articlenumber | 1625 | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.doi | 10.3390/nu15071625 | |
dc.identifier.cristin | 2144635 | |
dc.source.journal | Nutrients | en_US |
dc.relation.project | EC/H2020/728018 | en_US |
dc.identifier.citation | Nutrients. 2023, 15, 1625. | en_US |
dc.source.volume | 15 | en_US |
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