dc.contributor.author | Gyawali, Sanjay | |
dc.contributor.author | Lopez Cervantes, Juan Pablo | |
dc.contributor.author | Jögi, Nils Oskar | |
dc.contributor.author | Mustafa, Tehmina | |
dc.contributor.author | Johannessen, Ane | |
dc.contributor.author | Janson, Christer | |
dc.contributor.author | Holm, Mathias | |
dc.contributor.author | Modig, Lars | |
dc.contributor.author | Cramer, Christine | |
dc.contributor.author | Gislason, Thorarinn | |
dc.contributor.author | Svanes, Cecilie | |
dc.contributor.author | Shigdel, Rajesh | |
dc.date.accessioned | 2023-06-23T08:56:27Z | |
dc.date.available | 2023-06-23T08:56:27Z | |
dc.date.created | 2023-06-20T09:41:24Z | |
dc.date.issued | 2023 | |
dc.identifier.issn | 2312-0541 | |
dc.identifier.uri | https://hdl.handle.net/11250/3072860 | |
dc.description.abstract | Background: Tuberculosis (TB) infection induces profound local and systemic, immunological and inflammatory changes that could influence the development of other respiratory diseases; however, the association between TB and asthma is only partly understood. Our objective was to study the association of TB with asthma and respiratory symptoms in a Nordic–Baltic population-based study.
Methods: We included data from the Respiratory Health in Northern Europe (RHINE) study, in which information on general characteristics, TB infection, asthma and asthma-like symptoms were collected using standardised postal questionnaires. Asthma was defined based on asthma medication usage and/or asthma attacks 12 months prior to the study, and/or by a report of ≥three out of five respiratory symptoms in the last 12 months. Allergic/nonallergic asthma were defined as asthma with/without nasal allergy. The associations of TB with asthma outcomes were analysed using logistic regressions with adjustments for age, sex, smoking, body mass index and parental education.
Results: We included 8379 study participants aged 50–75 years, 61 of whom reported having had TB. In adjusted analyses, participants with a history of TB had higher odds of asthma (OR 1.99, 95% CI 1.13–3.47). The associations were consistent for nonallergic asthma (OR 2.17, 95% CI 1.16–4.07), but not for allergic asthma (OR 1.20, 95% CI 0.53–2.71).
Conclusion: We found that in a large Northern European population-based cohort, persons with a history of TB infection more frequently had asthma and asthma symptoms. We speculate that this may reflect long-term effects of TB, including direct damage to the airways and lungs, as well as inflammatory responses. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | European Respiratory Society | en_US |
dc.rights | Navngivelse-Ikkekommersiell 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/deed.no | * |
dc.title | Previous tuberculosis infection associated with increased frequency of asthma and respiratory symptoms in a Nordic–Baltic multicentre population study | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2023 the authors | en_US |
dc.source.articlenumber | 00011-2023 | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.doi | 10.1183/23120541.00011-2023 | |
dc.identifier.cristin | 2156062 | |
dc.source.journal | European Respiratory Journal Open Research (ERJ Open Research) | en_US |
dc.identifier.citation | European Respiratory Journal Open Research (ERJ Open Research). 2023, 9 (3), 00011-2023. | en_US |
dc.source.volume | 9 | en_US |
dc.source.issue | 3 | en_US |