dc.contributor.author | Mosevoll, Knut Anders | |
dc.contributor.author | Hansen, Bent-Are | |
dc.contributor.author | Gundersen, Ingunn Margareetta | |
dc.contributor.author | Reikvam, Håkon | |
dc.contributor.author | Bruserud, Øyvind | |
dc.contributor.author | Bruserud, Øystein | |
dc.contributor.author | Wendelbo, Øystein | |
dc.date.accessioned | 2023-07-07T08:16:56Z | |
dc.date.available | 2023-07-07T08:16:56Z | |
dc.date.created | 2023-03-11T13:00:11Z | |
dc.date.issued | 2023-01-24 | |
dc.identifier.issn | 2218-273X | |
dc.identifier.uri | https://hdl.handle.net/11250/3077039 | |
dc.description.abstract | Sepsis is a dysregulated host response to infection that causes potentially life-threatening organ dysfunction. We investigated the serum metabolomic profile at hospital admission for patients with bacterial sepsis. The study included 60 patients; 35 patients fulfilled the most recent 2016 Sepsis-3 criteria whereas the remaining 25 patients only fulfilled the previous Sepsis-2 criteria and could therefore be classified as having systemic inflammatory response syndrome (SIRS). A total of 1011 identified metabolites were detected in our serum samples. Ninety-seven metabolites differed significantly when comparing Sepsis-3 and Sepsis-2/SIRS patients; 40 of these metabolites constituted a heterogeneous group of amino acid metabolites/peptides. When comparing patients with and without bacteremia, we identified 51 metabolites that differed significantly, including 16 lipid metabolites and 11 amino acid metabolites. Furthermore, 42 metabolites showed a highly significant association with the maximal total Sequential Organ Failure Assessment (SOFA )score during the course of the disease (i.e., Pearson’s correlation test, p-value < 0.005, and correlation factor > 0.6); these top-ranked metabolites included 23 amino acid metabolites and a subset of pregnenolone/progestin metabolites. Unsupervised hierarchical clustering analyses based on all 42 top-ranked SOFA correlated metabolites or the subset of 23 top-ranked amino acid metabolites showed that most Sepsis-3 patients differed from Sepsis-2/SIRS patients in their systemic metabolic profile at the time of hospital admission. However, a minority of Sepsis-3 patients showed similarities with the Sepsis-2/SIRS metabolic profile even though several of them showed a high total SOFA score. To conclude, Sepsis-3 patients are heterogeneous with regard to their metabolic profile at the time of hospitalization. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | MDPI | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Systemic metabolomic profiles in adult patients with bacterial sepsis: Characterization of patient heterogeneity at the time of diagnosis | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2023 the authors | en_US |
dc.source.articlenumber | 223 | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.doi | 10.3390/biom13020223 | |
dc.identifier.cristin | 2133213 | |
dc.source.journal | Biomolecules | en_US |
dc.identifier.citation | Biomolecules. 2023, 13 (2), 223. | en_US |
dc.source.volume | 13 | en_US |
dc.source.issue | 2 | en_US |