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dc.contributor.authorMahjour Azad, Atabak
dc.contributor.authorBernhard, Annette
dc.contributor.authorShen, Anne
dc.contributor.authorMyrmel, Lene Secher
dc.contributor.authorLundebye, Anne-Katrine
dc.contributor.authorLecaudey, Laurene Alicia
dc.contributor.authorFjære, Even
dc.contributor.authorHo, Quang Tri
dc.contributor.authorSveier, Harald
dc.contributor.authorKristiansen, Karsten
dc.contributor.authorLimborg, Morten Tønsberg
dc.contributor.authorMadsen, Lise
dc.description.abstractAlternative feed ingredients for farmed salmon are warranted due to increasing pressure on wild fish stocks. As locally farmed blue mussels may represent an environmentally sustainable substitute with a lower carbon footprint, we aimed to test the potential and safety of substituting fish meal with blue mussel meal in feed for Atlantic salmon. Salmon were fed diets in which fish meal was partially replaced with blue mussel meal in increments, accounting for up to 13.1 % of the ingredients. Fillets from the salmon were subsequently used to prepare obesity-promoting western diets for a 13-weeks mouse feeding trial. In a second mouse trial, we tested the effects of inclusion of up to 8% blue mussel meal directly in a meat-based western diet. Partial replacement of fish meal with blue mussel meal in fish feed preserved the n-3 polyunsaturated fatty acid (PUFA) content in salmon fillets. The observed blue mussel-induced changes in the fatty acid profiles in salmon fillets did not translate into similar changes in the livers of mice that consumed the salmon, and no clear dose-dependent responses were found. The relative levels of the marine n-3 fatty acids, EPA, and DHA were not reduced, and the n-3/n-6 PUFA ratios in livers from all salmon-fed mice were unchanged. The inclusion of blue mussel meal in a meat-based western diet led to a small, but dose-dependent increase in the n-3/n-6 PUFA ratios in mice livers. Diet-induced obesity, glucose intolerance, and hepatic steatosis were unaffected in both mice trials and no blue mussel-induced adverse effects were observed. In conclusion, our results suggest that replacing fish meal with blue mussel meal in salmon feed will not cause adverse effects in those who consume the salmon fillets.en_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleMetabolic effects of diet containing blue mussel (Mytilus edulis) and blue mussel-fed salmon in a mouse model of obesityen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holderCopyright 2023 The Author(s).en_US
dc.source.journalFood Research Internationalen_US
dc.relation.projectNorges forskningsråd: 299554en_US
dc.identifier.citationFood Research International. 2023, 169, 112927.en_US

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal