Vis enkel innførsel

dc.contributor.authorTrøseid, Marius
dc.contributor.authorHolter, Jan Cato
dc.contributor.authorHolm, Kristian
dc.contributor.authorVestad, Beate
dc.contributor.authorSazonova, Taisiia
dc.contributor.authorGranerud, Beathe Kiland
dc.contributor.authorDyrhol-Riise, Anne Ma
dc.contributor.authorHolten, Aleksander Rygh
dc.contributor.authorTonby, Kristian
dc.contributor.authorKildal, Anders Benjamin
dc.contributor.authorHeggelund, Lars
dc.contributor.authorTveita, Anders Aune
dc.contributor.authorBøe, Simen
dc.contributor.authorMüller, Karl Erik
dc.contributor.authorJenum, Synne
dc.contributor.authorHov, Johannes Espolin Roksund
dc.contributor.authorUeland, Thor
dc.description.abstractBackground Gut microbiota alterations have been reported in hospitalized COVID-19 patients, with reduced alpha diversity and altered microbiota composition related to respiratory failure. However, data regarding gut microbiota and mortality are scarce. Methods Rectal swabs for gut microbiota analyses were collected within 48 h after hospital admission (baseline; n = 123) and three-month post-admission (n = 50) in a subset of patients included in the Norwegian SARS-CoV2 cohort study. Samples were analysed by sequencing the 16S rRNA gene. Gut microbiota diversity and composition at baseline were assessed in relation to need for intensive care unit (ICU) admission during hospitalization. The primary objective was to investigate whether the ICU-related gut microbiota was associated with 60-day mortality. Results Gut microbiota diversity (Shannon index) at baseline was lower in COVID-19 patients requiring ICU admission during hospitalization than in those managed in general wards. A dysbiosis index representing a balance of enriched and reduced taxa in ICU compared with ward patients, including decreased abundance of butyrate-producing microbes and enrichment of a partly oral bacterial flora, was associated with need of ICU admission independent of antibiotic use, dexamethasone use, chronic pulmonary disease, PO2/FiO2 ratio, C-reactive protein, neutrophil counts or creatinine levels (adjusted p < 0.001). The ICU-related dysbiosis index at baseline correlated with systemic inflammation and was associated with 60-day mortality in univariate analyses (Hazard ratio 3.70 [2.00–8.6], p < 0.001), as well as after separate adjustment for covariates. At the three-month follow-up, the dysbiosis index remained elevated in ICU patients compared with ward patients (adjusted p = 0.007). Conclusions Although our data should be regarded as exploratory due to low number of clinical end points, they suggest that gut microbiota alterations during hospitalization could be related to poor prognosis after severe COVID-19. Larger studies of gut involvement during COVID-19 in relation to long-term clinical outcome are warranted.en_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleGut microbiota composition during hospitalization is associated with 60-day mortality after severe COVID-19en_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holderCopyright The Author(s) 2023.en_US
dc.source.journalCritical Careen_US
dc.identifier.citationCritical Care. 2023, 27, 69.en_US

Tilhørende fil(er)


Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel

Navngivelse 4.0 Internasjonal
Med mindre annet er angitt, så er denne innførselen lisensiert som Navngivelse 4.0 Internasjonal