dc.contributor.author | O'Keeffe, Maria | |
dc.contributor.author | Oterhals, Åge | |
dc.contributor.author | Weishaupt, Hrafn | |
dc.contributor.author | Leh, Sabine | |
dc.contributor.author | Ulvik, Arve | |
dc.contributor.author | Ueland, Per Magne | |
dc.contributor.author | Halstensen, Alfred | |
dc.contributor.author | Marti, Hans Peter | |
dc.contributor.author | Gudbrandsen, Oddrun Anita | |
dc.date.accessioned | 2023-09-27T11:12:47Z | |
dc.date.available | 2023-09-27T11:12:47Z | |
dc.date.created | 2023-09-20T12:26:26Z | |
dc.date.issued | 2023 | |
dc.identifier.issn | 1436-6207 | |
dc.identifier.uri | https://hdl.handle.net/11250/3092362 | |
dc.description.abstract | Purpose
The obese black and tan, brachyuric (BTBR) ob/ob mouse spontaneously develops features comparable to human diabetic nephropathy. The primary aim of the present study was to investigate if a diet containing fish proteins would attenuate or delay the development of glomerular hypertrophy (glomerulomegaly), mesangial sclerosis and albuminuria in obese BTBR ob/ob mice.
Methods
Obese BTBR.CgLepob/WiscJ male mice were fed diets containing 25% of protein from Atlantic cod backbones and 75% of protein from casein (Cod-BB group), or casein as the sole protein source (control group). Kidneys were analysed morphologically, and markers for renal dysfunction were analysed biochemically in urine and serum.
Results
The Cod-BB diet attenuated the development of mesangial sclerosis (P 0.040) without affecting the development of glomerular hypertrophy and albuminuria. The urine concentration of cystatin C (relative to creatinine) was lower in mice fed the Cod-BB diet (P 0.0044).
Conclusion
A diet containing cod backbone protein powder attenuated the development of mesangial sclerosis and tubular dysfunction in obese BTBR ob/ob mice, but did not prevent the development of glomerular hypertrophy and albuminuria in these mice. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Springer | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | A diet containing cod backbone proteins attenuated the development of mesangial sclerosis and tubular dysfunction in male obese BTBR ob/ob mice | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2023 The Author(s) | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.doi | 10.1007/s00394-023-03227-4 | |
dc.identifier.cristin | 2177017 | |
dc.source.journal | European Journal of Nutrition | en_US |
dc.identifier.citation | European Journal of Nutrition. 2023. | en_US |