dc.contributor.author | Eikås, John Glad | |
dc.contributor.author | Gerdts, Eva | |
dc.contributor.author | Halland, Hilde | |
dc.contributor.author | Midtbø, Helga Bergljot | |
dc.contributor.author | Cramariuc, Dana | |
dc.contributor.author | Kringeland, Ester Anne | |
dc.date.accessioned | 2023-10-04T08:26:35Z | |
dc.date.available | 2023-10-04T08:26:35Z | |
dc.date.created | 2023-09-26T19:35:58Z | |
dc.date.issued | 2023 | |
dc.identifier.issn | 1120-9879 | |
dc.identifier.uri | https://hdl.handle.net/11250/3094036 | |
dc.description.abstract | Introduction: Obesity has been associated with increased arterial stiffness. Sex-differences in arterial stiffness in obesity have been less explored.
Aim: To explore sex-differences in arterial stiffness by applanation tonometry in 323 women and 225 with overweight and obesity, free of cardiovascular disease.
Methods: Covariables of arterial stiffness were identified in multivariable linear regression analyses in the total cohort and separately in women and men.
Results: In the total study cohort, women had higher augmentation pressure (AP) and augmentation index (AIx), and lower carotid-femoral pulse wave velocity (cf-PWV) than men, independent of confounders (all p < 0.001). In sex-specific analyses, higher AP was associated with higher age and 24-hours systolic blood pressure (BP), and with lower heart rate in women (all p < 0.001), and with higher age and BP in men (all p < 0.001). Similarly, higher AIx was associated with higher age and BP, and lower body mass index (BMI) and heart rate in women (all p < 0.05), and with higher age in men (all p < 0.001). Higher cf-PWV correlated with higher age and BP in women (all p < 0.005), and additionally with higher heart rate and non-smoking in men (all p < 0.05). When replacing BMI with waist-hip ratio, higher waist-hip ratio was associated with higher cf-PWV in men only (p < 0.05).
Conclusions: Among subjects with overweight and obesity, AP and AIx were higher in women, and cf-PWV was higher in men. Age and 24-hours systolic BP were the main factors associated with arterial stiffness in both sexes, while measures of adiposity had little impact on arterial stiffness. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Springer | en_US |
dc.rights | Navngivelse-Ikkekommersiell 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/deed.no | * |
dc.title | Arterial Stiffness in Overweight and Obesity: Association with Sex, Age, and Blood Pressure | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2023 the authors | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.doi | 10.1007/s40292-023-00593-2 | |
dc.identifier.cristin | 2179162 | |
dc.source.journal | High Blood Pressure & Cardiovascular Prevention | en_US |
dc.identifier.citation | High Blood Pressure & Cardiovascular Prevention. 2023. | en_US |