dc.contributor.author | May, Taymaa | |
dc.contributor.author | Bernardini, Marcus | |
dc.contributor.author | Lheureux, Stephanie | |
dc.contributor.author | Aben, Katja K.H. | |
dc.contributor.author | Bandera, Elisa V. | |
dc.contributor.author | Beckmann, Matthias W. | |
dc.contributor.author | Benitez, Javier | |
dc.contributor.author | Berchuck, Andrew | |
dc.contributor.author | Bjørge, Line | |
dc.contributor.author | Carney, Michael E. | |
dc.contributor.author | Cramer, Daniel W. | |
dc.contributor.author | Defazio, Anna | |
dc.contributor.author | Dörk, Thilo | |
dc.contributor.author | Eccles, Diana M. | |
dc.contributor.author | Friedlander, Michael | |
dc.contributor.author | García, María Jose | |
dc.contributor.author | Goode, Ellen L. | |
dc.contributor.author | Hein, Alexander | |
dc.contributor.author | Jensen, Allan | |
dc.contributor.author | Johnatty, Sharon | |
dc.contributor.author | Kennedy, Catherine J. | |
dc.contributor.author | Kiemeney, Lambertus A. | |
dc.contributor.author | Kjær, Susanne K. | |
dc.contributor.author | Kupryjanczyk, Jolanta | |
dc.contributor.author | Matsuo, Keitaro | |
dc.contributor.author | McGuire, Valerie | |
dc.contributor.author | Modugno, Francesmary | |
dc.contributor.author | Paddock, Lisa E. | |
dc.contributor.author | Pejovic, Tanja | |
dc.contributor.author | Phelan, Catherine M. | |
dc.contributor.author | Riggan, Marjorie J. | |
dc.contributor.author | Rodriguez-Antona, Cristina | |
dc.contributor.author | Rothstein, Joseph H. | |
dc.contributor.author | Sieh, Weiva | |
dc.contributor.author | Song, Honglin | |
dc.contributor.author | Terry, Kathryn L. | |
dc.contributor.author | Altena, Anne M. Van | |
dc.contributor.author | Vanderstichele, Adriaan | |
dc.contributor.author | Vergote, Ignace | |
dc.contributor.author | Thomsen, Liv Cecilie Vestrheim | |
dc.contributor.author | Webb, Penelope M. | |
dc.contributor.author | Wentzensen, Nicolas | |
dc.contributor.author | Wilkens, Lynne R. | |
dc.contributor.author | Ziogas, Argyrios | |
dc.contributor.author | Jiang, Haiyan | |
dc.contributor.author | Tone, Alicia | |
dc.date.accessioned | 2023-10-10T08:36:31Z | |
dc.date.available | 2023-10-10T08:36:31Z | |
dc.date.created | 2023-09-29T09:27:45Z | |
dc.date.issued | 2023 | |
dc.identifier.issn | 0820-3946 | |
dc.identifier.uri | https://hdl.handle.net/11250/3095395 | |
dc.description.abstract | Background: Women with low-grade ovarian serous carcinoma (LGSC) benefit from surgical treatment; however, the role of chemotherapy is controversial. We examined an international database through the Ovarian Cancer Association Consortium to identify factors that affect survival in LGSC.
Methods: We performed a retrospective cohort analysis of patients with LGSC who had had primary surgery and had overall survival data available. We performed univariate and multivariate analyses of progression-free survival and overall survival, and generated Kaplan–Meier survival curves.
Results: Of the 707 patients with LGSC, 680 (96.2%) had available overall survival data. The patients’ median age overall was 54 years. Of the 659 patients with International Federation of Obstetrics and Gynecology stage data, 156 (23.7%) had stage I disease, 64 (9.7%) had stage II, 395 (59.9%) had stage III, and 44 (6.7%) had stage IV. Of the 377 patients with surgical data, 200 (53.0%) had no visible residual disease. Of the 361 patients with chemotherapy data, 330 (91.4%) received first-line platinum-based chemotherapy. The median follow-up duration was 5.0 years. The median progression-free survival and overall survival were 43.2 months and 110.4 months, respectively. Multivariate analysis indicated a statistically significant impact of stage and residual disease on progression-free survival and overall survival. Platinum-based chemotherapy was not associated with a survival advantage.
Conclusion: This multicentre analysis indicates that complete surgical cytoreduction to no visible residual disease has the most impact on improved survival in LGSC. This finding could immediately inform and change practice. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Canadian Medical Association | en_US |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.no | * |
dc.title | Clinical parameters affecting survival outcomes in patients with low-grade serous ovarian carcinoma: An international multicentre analysis | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | publishedVersion | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.doi | 10.1503/cjs.017020 | |
dc.identifier.cristin | 2180134 | |
dc.source.journal | CMAJ - Canadian Medical Association Journal | en_US |
dc.source.pagenumber | E310-E320 | en_US |
dc.identifier.citation | CMAJ - Canadian Medical Association Journal. 2023, 66 (3), E310-E320. | en_US |
dc.source.volume | 66 | en_US |
dc.source.issue | 3 | en_US |