dc.contributor.author | Polok, Kamil | |
dc.contributor.author | Fronczek, Jakub | |
dc.contributor.author | Guidet, Bertrand | |
dc.contributor.author | Artigas, Antonio | |
dc.contributor.author | De Lange, Dylan W. | |
dc.contributor.author | Fjølner, Jesper | |
dc.contributor.author | Leaver, Susannah | |
dc.contributor.author | Beil, Michael | |
dc.contributor.author | Sviri, Sigal | |
dc.contributor.author | Bruno, Raphael Romano | |
dc.contributor.author | Wernly, Bernhard | |
dc.contributor.author | Pinto, Bernardo Bollen | |
dc.contributor.author | Schefold, Joerg C. | |
dc.contributor.author | Studzińska, Dorota | |
dc.contributor.author | Joannidis, Michael | |
dc.contributor.author | Oeyen, Sandra | |
dc.contributor.author | Marsh, Brian | |
dc.contributor.author | Andersen, Finn Husøy | |
dc.contributor.author | Moreno, Rui | |
dc.contributor.author | Cecconi, Maurizio | |
dc.contributor.author | Flaatten, Hans Kristian | |
dc.contributor.author | Jung, Christian | |
dc.contributor.author | Szczeklik, Wojciech | |
dc.date.accessioned | 2023-10-10T12:35:32Z | |
dc.date.available | 2023-10-10T12:35:32Z | |
dc.date.created | 2023-09-28T08:58:17Z | |
dc.date.issued | 2023 | |
dc.identifier.issn | 2110-5820 | |
dc.identifier.uri | https://hdl.handle.net/11250/3095523 | |
dc.description.abstract | Background
Non-invasive ventilation (NIV) has been commonly used to treat acute respiratory failure due to COVID-19. In this study we aimed to compare outcomes of older critically ill patients treated with NIV before and during the COVID-19 pandemic.
Methods
We analysed a merged cohort of older adults admitted to intensive care units (ICUs) due to respiratory failure. Patients were enrolled into one of two prospective observational studies: before COVID-19 (VIP2—2018 to 2019) and admitted due to COVID-19 (COVIP—March 2020 to January 2023). The outcomes included: 30-day mortality, intubation rate and NIV failure (death or intubation within 30 days).
Results
The final cohort included 1986 patients (1292 from VIP2, 694 from COVIP) with a median age of 83 years. NIV was used as a primary mode of respiratory support in 697 participants (35.1%). ICU admission due to COVID-19 was associated with an increased 30-day mortality (65.5% vs. 36.5%, HR 2.18, 95% CI 1.71 to 2.77), more frequent intubation (36.9% vs. 17.5%, OR 2.63, 95% CI 1.74 to 3.99) and NIV failure (76.2% vs. 45.3%, OR 4.21, 95% CI 2.84 to 6.34) compared to non-COVID causes of respiratory failure. Sensitivity analysis after exclusion of patients in whom life supporting treatment limitation was introduced during primary NIV confirmed higher 30-day mortality in patients with COVID-19 (52.5% vs. 23.4%, HR 2.64, 95% CI 1.83 to 3.80).
Conclusion
The outcomes of patients aged ≥80 years treated with NIV during COVID-19 pandemic were worse compared then those treated with NIV in the pre-pandemic era. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Springer | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Outcomes of patients aged ≥80 years with respiratory failure initially treated with non-invasive ventilation in European intensive care units before and during COVID-19 pandemic | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2023 The Author(s) | en_US |
dc.source.articlenumber | 82 | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.doi | 10.1186/s13613-023-01173-2 | |
dc.identifier.cristin | 2179687 | |
dc.source.journal | Annals of Intensive Care | en_US |
dc.identifier.citation | Annals of Intensive Care. 2023, 13 (1), 82. | en_US |
dc.source.volume | 13 | en_US |
dc.source.issue | 1 | en_US |