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dc.contributor.authorVigeland, Maria Dehli
dc.contributor.authorFlåm, Siri Tennebø
dc.contributor.authorVigeland, Magnus Dehli
dc.contributor.authorEspeland, Ansgar
dc.contributor.authorZucknick, Manuela
dc.contributor.authorWigemyr, Monica
dc.contributor.authorBråten, Lars Christian Haugli
dc.contributor.authorGjefsen, Elisabeth
dc.contributor.authorZwart, John Anker Henrik
dc.contributor.authorStorheim, Kjersti
dc.contributor.authorPedersen, Linda Margareth
dc.contributor.authorSelmer, Kaja Kristine
dc.contributor.authorLie, Benedicte Alexandra
dc.contributor.authorGervin, Kristina
dc.date.accessioned2023-10-12T12:46:46Z
dc.date.available2023-10-12T12:46:46Z
dc.date.created2023-09-26T15:09:59Z
dc.date.issued2023-07-21
dc.identifier.issn2079-6382
dc.identifier.urihttps://hdl.handle.net/11250/3096141
dc.description.abstractLong-term antibiotics are prescribed for a variety of medical conditions, recently including low back pain with Modic changes. The molecular impact of such treatment is unknown. We conducted longitudinal transcriptome and epigenome analyses in patients (n = 100) receiving amoxicillin treatment or placebo for 100 days in the Antibiotics in Modic Changes (AIM) study. Gene expression and DNA methylation were investigated at a genome-wide level at screening, after 100 days of treatment, and at one-year follow-up. We identified intra-individual longitudinal changes in gene expression and DNA methylation in patients receiving amoxicillin, while few changes were observed in patients receiving placebo. After 100 days of amoxicillin treatment, 28 genes were significantly differentially expressed, including the downregulation of 19 immunoglobulin genes. At one-year follow-up, the expression levels were still not completely restored. The significant changes in DNA methylation (n = 4548 CpGs) were mainly increased methylation levels between 100 days and one-year follow-up. Hence, the effects on gene expression occurred predominantly during treatment, while the effects on DNA methylation occurred after treatment. In conclusion, unrecognized side effects of long-term amoxicillin treatment were revealed, as alterations were observed in both gene expression and DNA methylation that lasted long after the end of treatment.en_US
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleLong-Term Use of Amoxicillin Is Associated with Changes in Gene Expression and DNA Methylation in Patients with Low Back Pain and Modic Changesen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2023 the authorsen_US
dc.source.articlenumber1217en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.doi10.3390/antibiotics12071217
dc.identifier.cristin2179083
dc.source.journalAntibioticsen_US
dc.identifier.citationAntibiotics. 2023, 12 (7), 1217.en_US
dc.source.volume12en_US
dc.source.issue7en_US


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