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dc.contributor.authorde Koning, Marie-Sophie L. Y.
dc.contributor.authorEmmens, Johanna E.
dc.contributor.authorRomero-Hernández, Esteban
dc.contributor.authorBourgonje, Arno R.
dc.contributor.authorAssa, Solmaz
dc.contributor.authorFigarska, Sylwia M.
dc.contributor.authorCleland, John G. F.
dc.contributor.authorSamani, Nilesh J.
dc.contributor.authorNg, Leong L.
dc.contributor.authorLang, Chim C.
dc.contributor.authorMetra, Marco
dc.contributor.authorFilippatos, Gerasimos S.
dc.contributor.authorvan Veldhuisen, Dirk J.
dc.contributor.authorAnker, Stefan D.
dc.contributor.authorDickstein, Kenneth
dc.contributor.authorVoors, Adriaan A.
dc.contributor.authorLipsic, Erik
dc.contributor.authorvan Goor, Harry
dc.contributor.authorvan der Harst, Pim
dc.description.abstractBackground: Oxidative stress may be a key pathophysiological mediator in the development and progression of heart failure (HF). The role of serum-free thiol concentrations, as a marker of systemic oxidative stress, in HF remains largely unknown. Objective: The purpose of this study was to investigate associations between serum-free thiol concentrations and disease severity and clinical outcome in patients with new-onset or worsening HF. Methods: Serum-free thiol concentrations were determined by colorimetric detection in 3802 patients from the BIOlogy Study to TAilored Treatment in Chronic Heart Failure (BIOSTAT-CHF). Associations between free thiol concentrations and clinical characteristics and outcomes, including all-cause mortality, cardiovascular mortality, and a composite of HF hospitalization and all-cause mortality during a 2-years follow-up, were reported. Results: Lower serum-free thiol concentrations were associated with more advanced HF, as indicated by worse NYHA class, higher plasma NT-proBNP (P < 0.001 for both) and with higher rates of all-cause mortality (hazard ratio (HR) per standard deviation (SD) decrease in free thiols: 1.253, 95% confidence interval (CI): 1.171–1.341, P < 0.001), cardiovascular mortality (HR per SD: 1.182, 95% CI: 1.086–1.288, P < 0.001), and the composite outcome (HR per SD: 1.058, 95% CI: 1.001–1.118, P = 0.046). Conclusions: In patients with new-onset or worsening HF, a lower serum-free thiol concentration, indicative of higher oxidative stress, is associated with increased HF severity and poorer prognosis. Our results do not prove causality, but our findings may be used as rationale for future (mechanistic) studies on serum-free thiol modulation in heart failure.en_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleSystemic oxidative stress associates with disease severity and outcome in patients with new-onset or worsening heart failureen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holderCopyright 2023 the authorsen_US
dc.source.journalClinical Research in Cardiologyen_US
dc.identifier.citationClinical Research in Cardiology. 2023, 112, 1056-1066.en_US

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal