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dc.contributor.authorBansal, Amit
dc.contributor.authorTrieu, Mai Chi
dc.contributor.authorMohn, Kristin Greve-Isdahl
dc.contributor.authorMadsen, Anders
dc.contributor.authorOlofsson, Jan Stefan
dc.contributor.authorSandnes, Helene Heitmann
dc.contributor.authorSævik, Marianne
dc.contributor.authorSøyland, Hanne
dc.contributor.authorHansen, Lena
dc.contributor.authorOnyango, Therese Bredholt
dc.contributor.authorTøndel, Camilla
dc.contributor.authorBrokstad, Karl Albert
dc.contributor.authorSyre, Heidi
dc.contributor.authorRiis, Åse Garløv
dc.contributor.authorLangeland, Nina
dc.contributor.authorCox, Rebecca Jane
dc.description.abstractBackground: Preventing infection in healthcare workers (HCWs) is crucial for protecting healthcare systems during the COVID-19 pandemic. Here, we investigated the seroepidemiology of SARS-CoV-2 in HCWs in Norway with low-transmission settings. Methods: From March 2020, we recruited HCWs at four medical centres. We determined infection by SARS-CoV-2 RT-PCR and serological testing and evaluated the association between infection and exposure variables, comparing our findings with global data in a meta-analysis. Anti-spike IgG antibodies were measured after infection and/or vaccination in a longitudinal cohort until June 2021. Results: We identified a prevalence of 10.5% (95% confidence interval, CI: 8.8–12.3) in 2020 and an incidence rate of 15.0 cases per 100 person-years (95% CI: 12.5–17.8) among 1,214 HCWs with 848 person-years of follow-up time. Following infection, HCWs (n = 63) mounted durable anti-spike IgG antibodies with a half-life of 4.3 months since their seropositivity. HCWs infected with SARS-CoV-2 in 2020 (n = 46) had higher anti-spike IgG titres than naive HCWs (n = 186) throughout the 5 months after vaccination with BNT162b2 and/or ChAdOx1-S COVID-19 vaccines in 2021. In a meta-analysis including 20 studies, the odds ratio (OR) for SARS-CoV-2 seropositivity was significantly higher with household contact (OR 12.6; 95% CI: 4.5–35.1) and occupational exposure (OR 2.2; 95% CI: 1.4–3.2). Conclusion: We found high and modest risks of SARS-CoV-2 infection with household and occupational exposure, respectively, in HCWs, suggesting the need to strengthen infection prevention strategies within households and medical centres. Infection generated long-lasting antibodies in most HCWs; therefore, we support delaying COVID-19 vaccination in primed HCWs, prioritising the non-infected high-risk HCWs amid vaccine shortage.en_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleRisk assessment and antibody responses to SARS-CoV-2 in healthcare workersen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.source.journalFrontiers in Public Healthen_US
dc.identifier.citationFrontiers in Public Health. 2023, 11, 1164326.en_US

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal