dc.contributor.author | Anthon, Carl Thomas | |
dc.contributor.author | Pène, Frédéric | |
dc.contributor.author | Perner, Anders | |
dc.contributor.author | Azoulay, Elie | |
dc.contributor.author | Puxty, Kathryn | |
dc.contributor.author | Van De Louw, Andry | |
dc.contributor.author | Barratt-Due, Andreas | |
dc.contributor.author | Chawla, Sanjay | |
dc.contributor.author | Castro, Pedro | |
dc.contributor.author | Póvoa, Pedro | |
dc.contributor.author | Coelho, Luis | |
dc.contributor.author | Metaxa, Victoria | |
dc.contributor.author | Kochanek, Matthias | |
dc.contributor.author | Liebregts, Tobias | |
dc.contributor.author | Kander, Thomas | |
dc.contributor.author | Hästbacka, Johanna | |
dc.contributor.author | Andreasen, Jo Bønding | |
dc.contributor.author | Péju, Edwige | |
dc.contributor.author | Nielsen, Lene Bjerregaard | |
dc.contributor.author | Hvas, Christine Lodberg | |
dc.contributor.author | Dufranc, Etienne | |
dc.contributor.author | Canet, Emmanuel | |
dc.contributor.author | Lundqvist, Linda | |
dc.contributor.author | Wright, Christopher John | |
dc.contributor.author | Schmidt, Julien | |
dc.contributor.author | Uhel, Fabrice | |
dc.contributor.author | Ait-Oufella, Hafid | |
dc.contributor.author | Krag, Mette | |
dc.contributor.author | Cos Badia, Elisabet | |
dc.contributor.author | Díaz-Lagares, Cándido | |
dc.contributor.author | Menat, Sophie | |
dc.contributor.author | Voiriot, Guillaume | |
dc.contributor.author | Clausen, Niels Erikstrup | |
dc.contributor.author | Lorentzen, Kristian | |
dc.contributor.author | Kvåle, Reidar | |
dc.contributor.author | Hildebrandt, Thomas | |
dc.contributor.author | Holten, Aleksander Rygh | |
dc.contributor.author | Strand, Kristian | |
dc.contributor.author | Tzalavras, Asterios | |
dc.contributor.author | Bestle, Morten Heiberg | |
dc.contributor.author | Klepstad, Pål | |
dc.contributor.author | Fernandez, Sara | |
dc.contributor.author | Vimpere, Damien | |
dc.contributor.author | Paulino, Carolina | |
dc.contributor.author | Graça, Carina | |
dc.contributor.author | Lueck, Catherina | |
dc.contributor.author | Juhl, Christian Svendsen | |
dc.contributor.author | Costa, Carolina | |
dc.contributor.author | Bådstøløkken, Per Martin | |
dc.contributor.author | Miranda, Teresa | |
dc.contributor.author | Lêdo, Lia Susana Aires | |
dc.contributor.author | Sousa Torres, Joao Carlos | |
dc.contributor.author | Granholm, Anders | |
dc.contributor.author | Møller, Morten Hylander | |
dc.contributor.author | Russell, Lene | |
dc.contributor.author | Khalil, Ahmed | |
dc.contributor.author | Yehia, Ahmed | |
dc.contributor.author | Salem, Haney | |
dc.contributor.author | Farahat, Hesham | |
dc.contributor.author | Sudevan, Manu | |
dc.contributor.author | Biggart, Melissa | |
dc.contributor.author | Fatima, Nirmeen | |
dc.contributor.author | Elkhonezy, Mohammed | |
dc.contributor.author | Bunzel, Anne-Marie | |
dc.contributor.author | Siegumfeldt, Rine M. | |
dc.contributor.author | Vestergaard, Stine R. | |
dc.contributor.author | Pelle, Juliette | |
dc.contributor.author | Lê, Minh-Pierre | |
dc.contributor.author | Vigneron, Clara | |
dc.contributor.author | Bertrix, Morgane | |
dc.contributor.author | Cirera, Paul | |
dc.contributor.author | Laghlam, Driss | |
dc.contributor.author | Bredin, Swann | |
dc.contributor.author | Marin, Nathalie | |
dc.contributor.author | Toppenberg, Maria | |
dc.contributor.author | Benelli, Brice | |
dc.contributor.author | Seguin, Amélie | |
dc.contributor.author | Garret, Charlotte | |
dc.contributor.author | Guillotin, Florian | |
dc.contributor.author | Blonz, Gauthier | |
dc.contributor.author | Lascarrou, Jean-Baptiste | |
dc.contributor.author | Lemarie, Jérémie | |
dc.contributor.author | Desmedt, Luc | |
dc.contributor.author | Agbakou, Maïté | |
dc.contributor.author | Carpentier, Mathieu | |
dc.contributor.author | Martin, Maëlle | |
dc.contributor.author | Benkalfate, Naïla | |
dc.contributor.author | Zambon, Olivier | |
dc.contributor.author | Decamps, Paul | |
dc.contributor.author | Wilquin, Pauline L. | |
dc.contributor.author | Benguerfi, Soraya | |
dc.contributor.author | Gardner, John | |
dc.contributor.author | Remor, Natalie | |
dc.contributor.author | Carr, Sheila | |
dc.contributor.author | Yang, Gloria | |
dc.contributor.author | Gernez, Coralie | |
dc.contributor.author | Thiry, Ingrid | |
dc.contributor.author | Missri, Louai | |
dc.contributor.author | Denneborg, Moritz K. G. | |
dc.contributor.author | Brown, Katherine | |
dc.contributor.author | Casares, Vanessa | |
dc.contributor.author | Sivula, Mirka | |
dc.contributor.author | Lappi, Elina | |
dc.contributor.author | Pettilä, Leena | |
dc.contributor.author | Heinonen, Jonna | |
dc.contributor.author | Saario, Minttu | |
dc.contributor.author | Mecheri, Manal K. | |
dc.contributor.author | Elabbadi, Alezandre | |
dc.contributor.author | Desnos, Cyrielle | |
dc.contributor.author | Lafarge, Antoine | |
dc.contributor.author | Mghirbi, Olfa | |
dc.contributor.author | Sjøbø, Brit Ågot | |
dc.contributor.author | Christoffersen, Cecilie | |
dc.contributor.author | Bestle, Frederik H. | |
dc.contributor.author | Lemos, Claudia | |
dc.contributor.author | Gonçalves, Cristiana V. | |
dc.contributor.author | Jacinto, Nuno M. B. | |
dc.contributor.author | Anselmo, Monica P. | |
dc.contributor.author | Hoeper, Marius M. | |
dc.contributor.author | Hoff, Marja | |
dc.contributor.author | Simões Freire, Pedro M. | |
dc.date.accessioned | 2024-01-17T12:03:10Z | |
dc.date.available | 2024-01-17T12:03:10Z | |
dc.date.created | 2023-10-31T09:54:20Z | |
dc.date.issued | 2023 | |
dc.identifier.issn | 0342-4642 | |
dc.identifier.uri | https://hdl.handle.net/11250/3112151 | |
dc.description.abstract | Purpose
Thrombocytopenia (platelet count < 150 × 109/L) is common in intensive care unit (ICU) patients and is likely associated with worse outcomes. In this study we present international contemporary data on thrombocytopenia in ICU patients.
Methods
We conducted a prospective cohort study in adult ICU patients in 52 ICUs across 10 countries. We assessed frequencies of thrombocytopenia, use of platelet transfusions and clinical outcomes including mortality. We evaluated pre-selected potential risk factors for the development of thrombocytopenia during ICU stay and associations between thrombocytopenia at ICU admission and 90-day mortality using pre-specified logistic regression analyses.
Results
We analysed 1166 ICU patients; the median age was 63 years and 39.5% were female. Overall, 43.2% (95% confidence interval (CI) 40.4–46.1) had thrombocytopenia; 23.4% (20–26) had thrombocytopenia at ICU admission, and 19.8% (17.6–22.2) developed thrombocytopenia during their ICU stay. Non-AIDS-, non-cancer-related immune deficiency, liver failure, male sex, septic shock, and bleeding at ICU admission were associated with the development of thrombocytopenia during ICU stay. Among patients with thrombocytopenia, 22.6% received platelet transfusion(s), and 64.3% of in-ICU transfusions were prophylactic. Patients with thrombocytopenia had higher occurrences of bleeding and death, fewer days alive without the use of life-support, and fewer days alive and out of hospital. Thrombocytopenia at ICU admission was associated with 90-day mortality (adjusted odds ratio 1.7; 95% CI 1.19–2.42).
Conclusion
Thrombocytopenia occurred in 43% of critically ill patients and was associated with worse outcomes including increased mortality. Platelet transfusions were given to 23% of patients with thrombocytopenia and most were prophylactic. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Springer | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Thrombocytopenia and platelet transfusions in ICU patients: an international inception cohort study (PLOT-ICU) | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2023 The Author(s) | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.doi | 10.1007/s00134-023-07225-2 | |
dc.identifier.cristin | 2190329 | |
dc.source.journal | Intensive Care Medicine | en_US |
dc.source.pagenumber | 1327–1338 | en_US |
dc.identifier.citation | Intensive Care Medicine. 2023, 49, 1327–1338. | en_US |
dc.source.volume | 49 | en_US |