dc.contributor.author | Lemaitre, Quentin Indiana Bruno | |
dc.contributor.author | Bartsch, Natascha | |
dc.contributor.author | Kouzel, Ivan | |
dc.contributor.author | Busengdal, Henriette | |
dc.contributor.author | Richards, Gemma Sian | |
dc.contributor.author | Steinmetz, Patrick | |
dc.contributor.author | Rentzsch, Fabian | |
dc.date.accessioned | 2024-01-17T12:51:25Z | |
dc.date.available | 2024-01-17T12:51:25Z | |
dc.date.created | 2023-10-10T12:24:21Z | |
dc.date.issued | 2023 | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | https://hdl.handle.net/11250/3112177 | |
dc.description.abstract | Neurogenesis has been studied extensively in the ectoderm, from which most animals generate the majority of their neurons. Neurogenesis from non-ectodermal tissue is, in contrast, poorly understood. Here we use the cnidarian Nematostella vectensis as a model to provide new insights into the molecular regulation of non-ectodermal neurogenesis. We show that the transcription factor NvPrdm14d is expressed in a subpopulation of NvSoxB(2)-expressing endodermal progenitor cells and their NvPOU4-expressing progeny. Using a new transgenic reporter line, we show that NvPrdm14d-expressing cells give rise to neurons in the body wall and in close vicinity of the longitudinal retractor muscles. RNA-sequencing of NvPrdm14d::GFP-expressing cells and gene knockdown experiments provide candidate genes for the development and function of these neurons. Together, the identification of a population of endoderm-specific neural progenitor cells and of previously undescribed putative motoneurons in Nematostella provide new insights into the regulation of non-ectodermal neurogenesis. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Nature | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | NvPrdm14d-expressing neural progenitor cells contribute to non-ectodermal neurogenesis in Nematostella vectensis | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2023 The Author(s) | en_US |
dc.source.articlenumber | 4854 | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.doi | 10.1038/s41467-023-39789-4 | |
dc.identifier.cristin | 2183309 | |
dc.source.journal | Nature Communications | en_US |
dc.identifier.citation | Nature Communications. 2023, 14 (1), 4854. | en_US |
dc.source.volume | 14 | en_US |
dc.source.issue | 1 | en_US |