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dc.contributor.authorPetrovic, Aleksandra
dc.contributor.authorBueide, Ingvild Øye
dc.contributor.authorTveit, Kåre Steinar
dc.contributor.authorHallaråker, Hogne
dc.contributor.authorBjørndal, Bodil
dc.contributor.authorHolmes, Timothy Dunstan
dc.contributor.authorDavies, Richard Allan
dc.contributor.authorBrokstad, Karl Albert
dc.contributor.authorBergum, Brith
dc.contributor.authorAppel, Silke
dc.date.accessioned2024-01-17T13:05:24Z
dc.date.available2024-01-17T13:05:24Z
dc.date.created2023-10-11T12:58:25Z
dc.date.issued2023
dc.identifier.issn1664-3224
dc.identifier.urihttps://hdl.handle.net/11250/3112187
dc.description.abstractBackground: Psoriasis is a chronic immune-mediated skin disease with systemic inflammation and comorbidities. Although the disease severity may vary over time, many patients suffer from mild to moderate disease. Often local treatment will be sufficient to control the symptoms, but they may have several side effects. ω-3 polyunsaturated fatty acids have shown promising results in clinical trials with mild-to-moderate psoriasis. Methods: We explored the impact of phospholipid bound docosahexaenoic acid and eicosapentaenoic acid in a 3:1 ratio on immune cells and cytokine networks in peripheral blood of patients with psoriasis. We investigated the inter-relation of plasma cytokine levels and disease severity in 58 patients, and explored the status of circulating immune cell activity in 18 patients with non-severe psoriasis before and during herring roe oil supplementation. Plasma concentration of 22 cytokines was measured by Luminex technology and circulating immune cells were analyzed by multicolor flow cytometry. Results: CCL2 levels decreased over time, and IFN-γR1 increased, possibly related to the action of ω-3 polyunsaturated fatty acids. We observed a shift from naïve to effector CD4+ T cells and decreases of CD38 expression on CD4+ and CD8+ T cells, CD56bright NK cells and CD14+CD16- classical monocytes. Conclusions: These findings support the beneficial effect of herring roe oil supplementation.en_US
dc.language.isoengen_US
dc.publisherFrontiersen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleHerring roe oil in treatment of psoriasis – influence on immune cells and cytokine networken_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.source.articlenumber1128986en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.doi10.3389/fimmu.2023.1128986
dc.identifier.cristin2183728
dc.source.journalFrontiers in Immunologyen_US
dc.identifier.citationFrontiers in Immunology. 2023, 14, 1128986.en_US
dc.source.volume14en_US


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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal