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dc.contributor.authorKisiel, Marta A.
dc.contributor.authorSedvall, Martin
dc.contributor.authorMalinovschi, Andrei
dc.contributor.authorFranklin, Karl A.
dc.contributor.authorGislason, Thorarinn
dc.contributor.authorShlunssen, Vivi
dc.contributor.authorJohansson, Ane
dc.contributor.authorModig, Lars
dc.contributor.authorJogi, Rain
dc.contributor.authorHolm, Mathias
dc.contributor.authorSvanes, Cecilie
dc.contributor.authorLindholdt, Louise
dc.contributor.authorCarlson, Marie
dc.contributor.authorJanson, Christer
dc.description.abstractBackground Asthma and inflammatory bowel disease (IBD) are common inflammatory diseases. The aim of this study was to investigate the associations of IBD with asthma and respiratory symptoms. Methods This study is based on 13,499 participants from seven northern European countries that filled in a postal questionnaire on asthma, respiratory symptoms, IBD including ulcerative colitis and Crohn's disease and various lifestyle variables. Results There were 195 participants with IBD. The prevalence of asthma (14.5 vs 8.1%, p = 0.001), different respiratory symptoms (range 11.9–36.8% vs range 6.0–18.6%, p < 0.005), non-infectious rhinitis (52.1 vs. 41.6%, p = 0.004) and chronic rhinosinusitis (11.6 vs 6.0%, p = 0.001) were higher in subjects with IBD than in those without IBD. In multivariable regression analysis, the association between IBD and asthma was statistically significant (OR 1.95 (95% CI 1.28–2.96)) after adjusting for confounders such as sex, BMI, smoking history, educational level and physical activity. There was a significant association between asthma and ulcerative colitis (adjusted OR 2.02 (95% CI 1.27–2.19)), and asthma but not Crohn's disease (adjusted OR 1.66 (95% CI 0.69–3.95)). A significant gender interaction was found with a significant association between IBD and asthma in women but not in men ((OR 2.72 (95% CI 1.67–4.46) vs OR 0.87 (95% CI 0.35–2.19), p = 0.038). Conclusions Patients with IBD, particularly those with ulcerative colitis and female, have a higher prevalence of asthma and respiratory symptoms. Our findings indicate that it is important to consider respiratory symptoms and disorders when examining patients with manifest or suspected IBD.en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.titleInflammatory bowel disease and asthma. Results from the RHINE studyen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.source.journalRespiratory Medicineen_US
dc.identifier.citationRespiratory Medicine. 2023, 216, 107307.en_US

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Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
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