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dc.contributor.authorPradeu, Thomas
dc.contributor.authorDaignan-Fornier, Bertrand
dc.contributor.authorEwald, Andrew
dc.contributor.authorGermain, Pierre-Luc
dc.contributor.authorOkasha, Samir
dc.contributor.authorPlutynski, Anya
dc.contributor.authorBenzekry, Sébastien
dc.contributor.authorBertolaso, Marta
dc.contributor.authorBissell, Mina
dc.contributor.authorBrown, Joel S.
dc.contributor.authorChin-Yee, Benjamin
dc.contributor.authorChin-Yee, Ian
dc.contributor.authorClevers, Hans
dc.contributor.authorCognet, Laurent
dc.contributor.authorDarrason, Marie
dc.contributor.authorFarge, Emmanuel
dc.contributor.authorFeunteun, Jean
dc.contributor.authorGalon, Jérôme
dc.contributor.authorGiroux, Elodie
dc.contributor.authorGreen, Sara
dc.contributor.authorGross, Fridolin
dc.contributor.authorJaulin, Fanny
dc.contributor.authorKnight, Rob
dc.contributor.authorLaconi, Ezio
dc.contributor.authorLarmonier, Nicolas
dc.contributor.authorMaley, Carlo
dc.contributor.authorMantovani, Alberto
dc.contributor.authorMoreau, Violaine
dc.contributor.authorNassoy, Pierre
dc.contributor.authorRondeau, Elena
dc.contributor.authorSantamaria, David
dc.contributor.authorSawai, Catherine M.
dc.contributor.authorSeluanov, Andrei
dc.contributor.authorSepich-Poore, Gregory D.
dc.contributor.authorSisirak, Vanja
dc.contributor.authorSolary, Eric
dc.contributor.authorYvonnet, Sarah
dc.contributor.authorLaplane, Lucie
dc.date.accessioned2024-03-11T09:15:51Z
dc.date.available2024-03-11T09:15:51Z
dc.date.created2023-06-08T13:37:02Z
dc.date.issued2023
dc.identifier.issn1464-7931
dc.identifier.urihttps://hdl.handle.net/11250/3121719
dc.description.abstractCancers rely on multiple, heterogeneous processes at different scales, pertaining to many biomedical fields. Therefore, understanding cancer is necessarily an interdisciplinary task that requires placing specialised experimental and clinical research into a broader conceptual, theoretical, and methodological framework. Without such a framework, oncology will collect piecemeal results, with scant dialogue between the different scientific communities studying cancer. We argue that one important way forward in service of a more successful dialogue is through greater integration of applied sciences (experimental and clinical) with conceptual and theoretical approaches, informed by philosophical methods. By way of illustration, we explore six central themes: (i) the role of mutations in cancer; (ii) the clonal evolution of cancer cells; (iii) the relationship between cancer and multicellularity; (iv) the tumour microenvironment; (v) the immune system; and (vi) stem cells. In each case, we examine open questions in the scientific literature through a philosophical methodology and show the benefit of such a synergy for the scientific and medical understanding of cancer.en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.no*
dc.titleReuniting philosophy and science to advance cancer researchen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.doi10.1111/brv.12971
dc.identifier.cristin2153071
dc.source.journalBiological Reviewsen_US
dc.source.pagenumber1668-1686en_US
dc.identifier.citationBiological Reviews. 2023, 98 (5), 1668-1686.en_US
dc.source.volume98en_US
dc.source.issue5en_US


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Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
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