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dc.contributor.authorHabbestad, Andrea Kyvik
dc.contributor.authorWillumsen, Johannes Sverre
dc.contributor.authorAarseth, Jan Harald
dc.contributor.authorGrytten, Nina
dc.contributor.authorMidgard, Rune
dc.contributor.authorWergeland, Stig
dc.contributor.authorMyhr, Kjell-Morten
dc.contributor.authorTorkildsen, Øivind
dc.description.abstractObjective To study the age at onset of relapsing–remitting multiple sclerosis (RRMS) during the past century. Methods This is a population-based cohort study of persons diagnosed with RRMS in Hordaland, Møre, and Romsdal counties, Western Norway, from 1920 to 2022. Individual patient data were available and assessed from previously conducted prevalence and incidence studies in addition to hospital records up until October 31, 2022. Participants were categorized according to onset period and analyzed for temporal trends in age at onset, time from onset to diagnosis, and distribution of onset over time. Results We identified 3364 persons with confirmed RRMS. The mean age at onset significantly increased (p < 0.001) throughout the study period, despite a decrease in time from symptom onset to diagnosis (p < 0.001). The proportion of persons with MS onset after 50 years of age increased from 2.6% before 1970 to 11.9% after 2010. We also found a trend toward a bimodal distribution of age at onset that peaked at around 30 years and 40–45 years of age in the latest period. Conclusion Age at onset of MS significantly increased throughout the study period. This was mainly due to an increasing number of persons with MS, predominantly female, experiencing onset after 40–45 years of age. This bimodal distribution could indicate different susceptibility periods of MS or changes in exposure to risk factors during the observation period.en_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleIncreasing age of multiple sclerosis onset from 1920 to 2022: a population-based studyen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.source.journalJournal of Neurologyen_US
dc.identifier.citationJournal of Neurology. 2023.en_US

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal