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dc.contributor.authorMørch, Kristine
dc.contributor.authorManoharan, Anand
dc.contributor.authorChandy, Sara
dc.contributor.authorSingh, Ashita
dc.contributor.authorKuriakose, Cijoy
dc.contributor.authorPatil, Suvarna
dc.contributor.authorHenry, Anil
dc.contributor.authorChacko, Novin
dc.contributor.authorAlvarez-Uria, Gerardo
dc.contributor.authorNesaraj, Joel
dc.contributor.authorBlomberg, Bjørn
dc.contributor.authorKurian, Siby
dc.contributor.authorHaanshuus, Christel Gill
dc.contributor.authorAntony, George
dc.contributor.authorLangeland, Nina
dc.contributor.authorMathai, Dilip
dc.description.abstractBackground Acute undifferentiated fever (AUF) ranges from self-limiting illness to life-threatening infections, such as sepsis, malaria, dengue, leptospirosis and rickettsioses. Similar clinical presentation challenges the clinical management. This study describes risk factors for death in patients hospitalized with AUF in India. Methods Patients aged ≥5 y admitted with fever for 2–14 d without localizing signs were included in a prospective observational study at seven hospitals in India during 2011–2012. Predictors identified by univariate analysis were analyzed by multivariate logistic regression for survival analysis. Results Mortality was 2.4% (37/1521) and 46.9% (15/32) died within 2 d. History of heart disease (p=0.013), steroid use (p=0.011), altered consciousness (p<0.0001), bleeding (p<0.0001), oliguria (p=0.020) and breathlessness (p=0.015) were predictors of death, as were reduced Glasgow coma score (p=0.005), low urinary output (p=0.004), abnormal breathing (p=0.006), abdominal tenderness (p=0.023), leucocytosis (p<0.0001) and thrombocytopenia (p=0.001) at admission. Etiology was identified in 48.6% (18/37) of fatal cases. Conclusions Bleeding, cerebral dysfunction, respiratory failure and oliguria at admission, suggestive of severe organ failure secondary to systemic infection, were predictors of death. Almost half of the patients who died, died shortly after admission, which, together with organ failure, suggests that delay in hospitalization and, consequently, delayed treatment, contribute to death from AUF.en_US
dc.publisherOxford University Pressen_US
dc.rightsNavngivelse-Ikkekommersiell 4.0 Internasjonal*
dc.titleClinical features and risk factors for death in acute undifferentiated fever: A prospective observational study in rural community hospitals in six states of Indiaen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.source.journalTransactions of the Royal Society of Tropical Medicine and Hygieneen_US
dc.identifier.citationTransactions of the Royal Society of Tropical Medicine and Hygiene. 2023, 117 (2), 91-101.en_US

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Navngivelse-Ikkekommersiell 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse-Ikkekommersiell 4.0 Internasjonal