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dc.contributor.authorHeradstveit, Bård Einar
dc.contributor.authorSunde, Geir Arne
dc.contributor.authorAsbjørnsen, Helge
dc.contributor.authorAalvik, Rune
dc.contributor.authorWentzel-Larsen, Tore
dc.contributor.authorHeltne, Jon-Kenneth
dc.date.accessioned2024-04-19T08:39:39Z
dc.date.available2024-04-19T08:39:39Z
dc.date.created2023-11-15T12:14:15Z
dc.date.issued2023
dc.identifier.issn0300-9572
dc.identifier.urihttps://hdl.handle.net/11250/3127367
dc.description.abstractAim of the study: Epinephrine has been recommended for several decades for the treatment of cardiac arrest. However, although this potent medicament has a documented impact on the return of spontaneous circulation, it does not improve long-term survival. Decreased cerebral blood flow, one of the side effects of epinephrine, indicates that the use of this drug is a two-edged sword. Despite clinical recommendations, no study has investigated epinephrine pharmacokinetics in a setting of cardiac arrest. Therefore, in a pilot setting, we measured the plasma concentrations of epinephrine following a single administration. Methods: Nine patients with cardiac arrest were included in our study. A single dose of 1 mg epinephrine was administered into a peripheral vein. Simultaneously, blood samples were withdrawn every minute from the jugular vein to determine the plasma concentration. A mixed effects model was used to estimate the T1/2 following the peak concentration. Results: One patient did not achieve a peak concentration during observation and was hence excluded. The remaining eight patients had 26 measurements suitable for modelling. In a stable model, the decline is estimated to be −0.259 [95 % CI (-0.361, −0.157) (p < 0.001)]. This implies a half-time for epinephrine of 2.6 (1.9, 4.4) minutes. Conclusion: Our study indicates that elimination of epinephrine during cardiac arrest is prolonged and that repeated doses of epinephrine may lead to increased plasma levels. Further and larger studies are warranted to determine the optimal plasma concentration during resuscitation.en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titlePharmacokinetics of epinephrine during cardiac arrest: A pilot studyen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2023 the authorsen_US
dc.source.articlenumber110025en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2
dc.identifier.doi10.1016/j.resuscitation.2023.110025
dc.identifier.cristin2197018
dc.source.journalResuscitationen_US
dc.identifier.citationResuscitation. 2023, 193, 110025.en_US
dc.source.volume193en_US


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