dc.contributor.author | Thulin, Ingrid Viola Lavesson | |
dc.contributor.author | Jordalen, Silje Marie Farestveit | |
dc.contributor.author | Lekven, Ole Christian | |
dc.contributor.author | Krishnapillai, Jeyaseelan | |
dc.contributor.author | Steiro, Ole-Thomas | |
dc.contributor.author | Collinson, Paul | |
dc.contributor.author | Apple, Fred | |
dc.contributor.author | Cullen, Louise | |
dc.contributor.author | Norekvål, Tone Merete | |
dc.contributor.author | Wisløff, Torbjørn | |
dc.contributor.author | Vikenes, Kjell | |
dc.contributor.author | Omland, Torbjørn | |
dc.contributor.author | Bjørneklett, Rune Oskar | |
dc.contributor.author | Aakre, Kristin Moberg | |
dc.date.accessioned | 2024-05-08T13:14:44Z | |
dc.date.available | 2024-05-08T13:14:44Z | |
dc.date.created | 2023-11-22T17:27:01Z | |
dc.date.issued | 2023 | |
dc.identifier.issn | 1401-7431 | |
dc.identifier.uri | https://hdl.handle.net/11250/3129780 | |
dc.description.abstract | Objectives: Patients presenting with symptoms suggestive of acute coronary syndrome (ACS) contribute to a high workload and overcrowding in the Emergency Department (ED). Accelerated diagnostic protocols for non-ST-elevation myocardial infarction have proved challenging to implement. One obstacle is the turnaround time for analyzing high-sensitivity cardiac troponin (hs-cTn). In the WESTCOR-POC study (Clinical Trials number NCT05354804) we aim to evaluate safety and efficiency of a 0/1 h hs-cTn algorithm utilizing a hs-cTnI point of care (POC) instrument in comparison to central laboratory hs-cTnT measurements.
Design: This is a prospective single-center randomized clinical trial aiming to include 1500 patients admitted to the ED with symptoms suggestive of ACS. Patients will receive standard investigations following the European Society of Cardiology 0/1h protocols for centralized hs-cTnT measurements or the intervention using a 0/1h POC hs-cTnI algorithm. Primary end-points are 1) Safety; death, myocardial infarction or acute revascularization within 30 days 2) Efficiency; length of stay in the ED, 3) Cost- effectiveness; total episode cost, 4) Patient satisfaction, 5) Patient symptom burden and 6) Patients quality of life. Secondary outcomes are 12-months death, myocardial infarction or acute revascularization, percentage discharged after 3 and 6 h, total length of hospital stay and all costs related to hospital contact within 12 months.
Conclusion: Results from this study may facilitate implementation of POC hs-cTn testing assays and accelerated diagnostic protocols in EDs, and may serve as a valuable resource for guiding future investigations for the use of POC high sensitivity troponin assays in outpatient clinics and prehospital settings. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Taylor & Francis | en_US |
dc.rights | Navngivelse-Ikkekommersiell 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/deed.no | * |
dc.title | Aiming toWards Evidence baSed inTerpretation of Cardiac biOmarkers in patients pResenting with chest pain using Point of Care Testing (WESTCOR-POC): study design | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2023 the authors | en_US |
dc.source.articlenumber | 2272585 | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.doi | 10.1080/14017431.2023.2272585 | |
dc.identifier.cristin | 2200524 | |
dc.source.journal | Scandinavian Cardiovascular Journal | en_US |
dc.identifier.citation | Scandinavian Cardiovascular Journal. 2023, 57 (1), 2272585. | en_US |
dc.source.volume | 57 | en_US |
dc.source.issue | 1 | en_US |