dc.contributor.author | Magnus, Maria Christine | |
dc.contributor.author | Örtqvist, Anne K. | |
dc.contributor.author | Urhoj, Stine Kjaer | |
dc.contributor.author | Aabakke, Anna | |
dc.contributor.author | Mortensen, Laust Hvas | |
dc.contributor.author | Gjessing, Håkon K. | |
dc.contributor.author | Andersen, Anne-Marie Nybø | |
dc.contributor.author | Stephansson, Olof | |
dc.contributor.author | Håberg, Siri Eldevik | |
dc.date.accessioned | 2024-05-13T11:00:37Z | |
dc.date.available | 2024-05-13T11:00:37Z | |
dc.date.created | 2023-11-27T12:05:27Z | |
dc.date.issued | 2023 | |
dc.identifier.issn | 2753-4294 | |
dc.identifier.uri | https://hdl.handle.net/11250/3130094 | |
dc.description.abstract | Background: A few studies indicate that women infected with SARS-CoV-2 during pregnancy might have an increased risk of stillbirth. Our aim was to investigate the risk of stillbirth according to infection with SARS-CoV-2 during pregnancy also taking the variant into account.
Methods: We conducted a register-based study using the Swedish, Danish and Norwegian birth registries. A total of 389 949 births (1013 stillbirths) after 22 completed gestational weeks between 1 May 2020 and end of follow-up (27 January 2022 for Sweden and Norway; 31 December 2021 for Denmark). We estimated the risk of stillbirth following SARS-CoV-2 infection after 22 completed gestational weeks using Cox regression for each country, and combined the results using a random-effects meta-analysis.
Results: SARS-CoV-2 infection after 22 completed gestational weeks was associated with an increased risk of stillbirth (adjusted HR 2.40; 95% CI 1.22 to 4.71). The risk was highest during the first weeks following infection, with an adjusted HR of 5.48 (95% CI 3.11 to 9.63) during the first 2 weeks, 4.38 (95% CI 2.41 to 7.98) during the first 4 weeks, and 3.71 (95% CI 1.81 to 7.59) during the first 6 weeks. Furthermore, the risk was greatest among women infected during the Delta-dominated period (adjusted HR 8.23; 95% CI 3.65 to 18.59), and more modest among women infected during the Index (adjusted HR 3.66; 95% CI 1.89 to 7.06) and Alpha (adjusted HR 2.73; 95% CI 1.13 to 6.59) dominated periods.
Conclusions: We found an increased risk of stillbirth among women who were infected with SARS-CoV-2 after 22 gestational weeks, with the greatest risk during the Delta-dominated period. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | BMJ | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Infection with SARS-CoV-2 during pregnancy and risk of stillbirth: a Scandinavian registry study | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2023 the authors | en_US |
dc.source.articlenumber | e000314 | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 0 | |
dc.identifier.doi | 10.1136/bmjph-2023-000314 | |
dc.identifier.cristin | 2202864 | |
dc.source.journal | BMJ Public Health | en_US |
dc.relation.project | Nordforsk: 135876 | en_US |
dc.relation.project | EC/H2020/947684 | en_US |
dc.relation.project | Nordforsk: 105545 | en_US |
dc.relation.project | Norges forskningsråd: 324312 | en_US |
dc.relation.project | Norges forskningsråd: 262700 | en_US |
dc.identifier.citation | BMJ Public Health. 2023, 1 (1), e000314. | en_US |
dc.source.volume | 1 | en_US |
dc.source.issue | 1 | en_US |