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dc.contributor.authorFritz, Josef
dc.contributor.authorJochems, Sylvia H. J.
dc.contributor.authorBjørge, Tone
dc.contributor.authorWood, Angela M.
dc.contributor.authorHäggström, Christel
dc.contributor.authorUlmer, Hanno
dc.contributor.authorNagel, Gabriele
dc.contributor.authorZitt, Emanuel
dc.contributor.authorEngeland, Anders
dc.contributor.authorHarlid, Sophia
dc.contributor.authorDrake, Isabel
dc.contributor.authorStattin, Pär
dc.contributor.authorStocks, Tanja
dc.date.accessioned2024-06-07T08:29:27Z
dc.date.available2024-06-07T08:29:27Z
dc.date.created2024-01-04T13:42:00Z
dc.date.issued2024
dc.identifier.issn0007-0920
dc.identifier.urihttps://hdl.handle.net/11250/3133015
dc.description.abstractBackground Insulin resistance is a hypothesised biological mechanism linking obesity with prostate cancer (PCa) death. Data in support of this hypothesis is limited. Methods We included 259,884 men from eight European cohorts, with 11,760 incident PCa’s and 1784 PCa deaths during follow-up. We used the triglyceride-glucose (TyG) index as indicator of insulin resistance. We analysed PCa cases with follow-up from PCa diagnosis, and the full cohort with follow-up from the baseline cancer-free state, thus incorporating both PCa incidence and death. We calculated hazard ratios (HR) and the proportion of the total effect of body mass index (BMI) on PCa death mediated through TyG index. Results In the PCa-case-only analysis, baseline TyG index was positively associated with PCa death (HR per 1-standard deviation: 1.11, 95% confidence interval (CI); 1.01–1.22), and mediated a substantial proportion of the baseline BMI effect on PCa death (HRtotal effect per 5-kg/m2 BMI: 1.24; 1.14–1.35, of which 28%; 4%–52%, mediated). In contrast, in the full cohort, the TyG index was not associated with PCa death (HR: 1.03; 0.94-1.13), hence did not substantially mediate the effect of BMI on PCa death. Conclusions Insulin resistance could be an important pathway through which obesity accelerates PCa progression to death.en_US
dc.language.isoengen_US
dc.publisherNatureen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleBody mass index, triglyceride-glucose index, and prostate cancer death: a mediation analysis in eight European cohortsen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2
dc.identifier.doi10.1038/s41416-023-02526-1
dc.identifier.cristin2220657
dc.source.journalBritish Journal of Canceren_US
dc.source.pagenumber308-316en_US
dc.identifier.citationBritish Journal of Cancer. 2025, 130, 308-316.en_US
dc.source.volume130en_US


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