dc.contributor.author | Verhoef, Ellen | |
dc.contributor.author | Allegrini, Andrea G. | |
dc.contributor.author | Jansen, Philip R. | |
dc.contributor.author | Lange, Katherine | |
dc.contributor.author | Wang, Carol A. | |
dc.contributor.author | Morgan, Angela | |
dc.contributor.author | Ahluwalia, Tarunveer S. | |
dc.contributor.author | Symeonides, Christos | |
dc.contributor.author | Eising, Else | |
dc.contributor.author | Franken, Marie-Christine | |
dc.contributor.author | Hypponen, Elina | |
dc.contributor.author | Mansell, Toby | |
dc.contributor.author | Olislagers, Mitchell | |
dc.contributor.author | Omerovic, Emina | |
dc.contributor.author | Rimfeld, Kaili | |
dc.contributor.author | Schlag, Fenja | |
dc.contributor.author | Selzam, Saskia | |
dc.contributor.author | Shapland, Chin Yang | |
dc.contributor.author | Tiemeier, Henning | |
dc.contributor.author | Whitehouse, Andrew J.O. | |
dc.contributor.author | Saffery, Richard | |
dc.contributor.author | Bønnelykke, Klaus | |
dc.contributor.author | Reilly, Sheena | |
dc.contributor.author | Pennell, Craig E. | |
dc.contributor.author | Wake, Melissa | |
dc.contributor.author | Cecil, Charlotte A. M. | |
dc.contributor.author | Plomin, Robert | |
dc.contributor.author | Fisher, Simon E. | |
dc.contributor.author | St Pourcain, Beate | |
dc.contributor.author | Andreassen, Ole | |
dc.contributor.author | Bartels, Meike | |
dc.contributor.author | Boomsma, Dorret | |
dc.contributor.author | Dale, Philip S. | |
dc.contributor.author | Ehli, Erik | |
dc.contributor.author | Fernandez-Orth, Dietmar | |
dc.contributor.author | Guxens, Mònica | |
dc.contributor.author | Hakulinen, Christian | |
dc.contributor.author | Harris, Kathleen Mullan | |
dc.contributor.author | Haworth, Simon | |
dc.contributor.author | de Hoyos, Lucía | |
dc.contributor.author | Jaddoe, Vincent | |
dc.contributor.author | Keltikangas-Järvinen, Liisa | |
dc.contributor.author | Lehtimäki, Terho | |
dc.contributor.author | Middeldorp, Christel | |
dc.contributor.author | Min, Josine L. | |
dc.contributor.author | Mishra, Pashupati P. | |
dc.contributor.author | Njølstad, Pål Rasmus | |
dc.contributor.author | Sunyer, Jordi | |
dc.contributor.author | Tate, Ashley E. | |
dc.contributor.author | Timpson, Nicholas | |
dc.contributor.author | van der Laan, Camiel | |
dc.contributor.author | Vrijheid, Martine | |
dc.contributor.author | Vuoksimaa, Eero | |
dc.contributor.author | Whipp, Alyce M. | |
dc.contributor.author | Ystrøm, Eivind | |
dc.date.accessioned | 2024-08-01T07:20:22Z | |
dc.date.available | 2024-08-01T07:20:22Z | |
dc.date.created | 2024-01-30T15:25:10Z | |
dc.date.issued | 2024 | |
dc.identifier.issn | 0006-3223 | |
dc.identifier.uri | https://hdl.handle.net/11250/3143964 | |
dc.description.abstract | Background
The number of words children produce (expressive vocabulary) and understand (receptive vocabulary) changes rapidly during early development, partially due to genetic factors. Here, we performed a meta–genome-wide association study of vocabulary acquisition and investigated polygenic overlap with literacy, cognition, developmental phenotypes, and neurodevelopmental conditions, including attention-deficit/hyperactivity disorder (ADHD).
Methods
We studied 37,913 parent-reported vocabulary size measures (English, Dutch, Danish) for 17,298 children of European descent. Meta-analyses were performed for early-phase expressive (infancy, 15–18 months), late-phase expressive (toddlerhood, 24–38 months), and late-phase receptive (toddlerhood, 24–38 months) vocabulary. Subsequently, we estimated single nucleotide polymorphism–based heritability (SNP-h2) and genetic correlations (rg) and modeled underlying factor structures with multivariate models.
Results
Early-life vocabulary size was modestly heritable (SNP-h2 = 0.08–0.24). Genetic overlap between infant expressive and toddler receptive vocabulary was negligible (rg = 0.07), although each measure was moderately related to toddler expressive vocabulary (rg = 0.69 and rg = 0.67, respectively), suggesting a multifactorial genetic architecture. Both infant and toddler expressive vocabulary were genetically linked to literacy (e.g., spelling: rg = 0.58 and rg = 0.79, respectively), underlining genetic similarity. However, a genetic association of early-life vocabulary with educational attainment and intelligence emerged only during toddlerhood (e.g., receptive vocabulary and intelligence: rg = 0.36). Increased ADHD risk was genetically associated with larger infant expressive vocabulary (rg = 0.23). Multivariate genetic models in the ALSPAC (Avon Longitudinal Study of Parents and Children) cohort confirmed this finding for ADHD symptoms (e.g., at age 13; rg = 0.54) but showed that the association effect reversed for toddler receptive vocabulary (rg = −0.74), highlighting developmental heterogeneity.
Conclusions
The genetic architecture of early-life vocabulary changes during development, shaping polygenic association patterns with later-life ADHD, literacy, and cognition-related traits. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Genome-wide analyses of vocabulary size in infancy and toddlerhood: associations with ADHD, literacy and cognition-related traits | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2023 Society of Biological Psychiatry | en_US |
cristin.ispublished | false | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.doi | 10.1016/j.biopsych.2023.11.025 | |
dc.identifier.cristin | 2238554 | |
dc.source.journal | Biological Psychiatry | en_US |
dc.source.pagenumber | 859-869 | en_US |
dc.relation.project | Norges forskningsråd: 262177 | en_US |
dc.relation.project | Norges forskningsråd: 273291 | en_US |
dc.relation.project | Helse Vest RHF: Personalized Medicine for Children and Adults | en_US |
dc.relation.project | Norges forskningsråd: 240413 | en_US |
dc.relation.project | Stiftelsen Kristian Gerhard Jebsen: | en_US |
dc.relation.project | Novo Nordisk Fonden: 54741 | en_US |
dc.relation.project | Norges forskningsråd: 324252 | en_US |
dc.relation.project | EC/H2020/848158 | en_US |
dc.relation.project | Andre: | en_US |
dc.relation.project | ERC-European Research Council: 293574 | en_US |
dc.relation.project | Novo Nordisk Fonden: NNF18OC0052457 | en_US |
dc.relation.project | Norges forskningsråd: 288083 | en_US |
dc.relation.project | Andre: CPII18/00018 | en_US |
dc.relation.project | UiT Norges arktiske universitet: | en_US |
dc.relation.project | Universitetet i Bergen: | en_US |
dc.relation.project | Norges forskningsråd: 223273 | en_US |
dc.relation.project | Andre: MC_UU_00032/02 | en_US |
dc.relation.project | Andre: CEX2018-000806-S | en_US |
dc.relation.project | National Institutes of Health: | en_US |
dc.relation.project | Bergens forskningsstiftelse: Utilizing the Mother and Child Cohort and the Medical Birth | en_US |
dc.identifier.citation | Biological Psychiatry. 2024, 95 (9), 859-869 | en_US |
dc.source.volume | 95 | en_US |
dc.source.issue | 9 | en_US |