dc.contributor.author | Shein, Aye Mya Sithu | |
dc.contributor.author | Wannigama, Dhammika Leshan | |
dc.contributor.author | Hurst, Cameron | |
dc.contributor.author | Monk, Peter N. | |
dc.contributor.author | Amarasiri, Mohan | |
dc.contributor.author | Badavath, Vishnu Nayak | |
dc.contributor.author | Phattharapornjaroen, Phatthranit | |
dc.contributor.author | Ditcham, William Graham Fox | |
dc.contributor.author | Ounjai, Puey | |
dc.contributor.author | Saethang, Thammakorn | |
dc.contributor.author | Chantaravisoot, Naphat | |
dc.contributor.author | Thuptimdang, Wanwara | |
dc.contributor.author | Luk-in, Sirirat | |
dc.contributor.author | Nilgate, Sumanee | |
dc.contributor.author | Rirerm, Ubolrat | |
dc.contributor.author | Tanasatitchai, Chanikan | |
dc.contributor.author | Kueakulpattana, Naris | |
dc.contributor.author | Laowansiri, Matchima | |
dc.contributor.author | Liao, Tingting | |
dc.contributor.author | Kupwiwat, Rosalyn | |
dc.contributor.author | Rojanathanes, Rojrit | |
dc.contributor.author | Ngamwongsatit, Natharin | |
dc.contributor.author | Thammahong, Arsa | |
dc.contributor.author | Ishikawa, Hitoshi | |
dc.contributor.author | Pletzer, Daniel | |
dc.contributor.author | Leelahavanichkul, Asada | |
dc.contributor.author | Ragupathi, Naveen Kumar Devanga | |
dc.contributor.author | Wapeesittipan, Pattama | |
dc.contributor.author | Ali Hosseini Rad, Hosseini | |
dc.contributor.author | Kanjanabuch, Talerngsak | |
dc.contributor.author | Storer, Robin James | |
dc.contributor.author | Miyanaga, Kazuhiko | |
dc.contributor.author | Cui, Longzhu | |
dc.contributor.author | Hamamoto, Hiroshi | |
dc.contributor.author | Higgins, Paul G. | |
dc.contributor.author | Kicic, Anthony | |
dc.contributor.author | Chatsuwan, Tanittha | |
dc.contributor.author | Hongsing, Parichart | |
dc.contributor.author | Abe, Shuichi | |
dc.date.accessioned | 2024-08-01T08:57:20Z | |
dc.date.available | 2024-08-01T08:57:20Z | |
dc.date.created | 2023-11-14T13:57:06Z | |
dc.date.issued | 2023 | |
dc.identifier.issn | 0753-3322 | |
dc.identifier.uri | https://hdl.handle.net/11250/3144011 | |
dc.description.abstract | Given the rise of multidrug-resistant (MDR) Pseudomonas aeruginosa infections, alternative treatments are needed. Anti-pseudomonal phage therapy shows promise, but its clinical application is limited due to the development of resistance and a lack of biofilm penetration. Recently, adjuvants like CaEDTA have shown the ability to enhance the effectiveness of combined antimicrobial agents. Here, we tested a phage-adjuvant combination and demonstrated the effectiveness of intranasally inhaled phage (KKP10) + CaEDTA in addition to ceftazidime/avibactam (CZA) for chronic P. aeruginosa lung infections. The results emphasize that intranasal inhalation of phage along with CaEDTA can successfully re-sensitize MDR P. aeruginosa to CZA in a triple combination treatment. This promising approach shows potential as a therapy for chronic respiratory tract infections. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.no | * |
dc.title | Novel intranasal phage-CaEDTA-ceftazidime/avibactam triple combination therapy demonstrates remarkable efficacy in treating Pseudomonas aeruginosa lung infection | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2023 The Author(s) | en_US |
dc.source.articlenumber | 115793 | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.doi | 10.1016/j.biopha.2023.115793 | |
dc.identifier.cristin | 2196528 | |
dc.source.journal | Biomedicine & Pharmacotherapy | en_US |
dc.identifier.citation | Biomedicine & Pharmacotherapy. 2023, 168, 115793. | en_US |
dc.source.volume | 168 | en_US |