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dc.contributor.authorNakken, Charlotte Langeland
dc.contributor.authorMeier, Sonnich
dc.contributor.authorMjøs, Svein Are
dc.contributor.authorBijlsma, Lubertus
dc.contributor.authorRowland, Steven J
dc.contributor.authorDonald, Carey
dc.date.accessioned2024-08-01T13:13:03Z
dc.date.available2024-08-01T13:13:03Z
dc.date.created2024-02-18T10:47:14Z
dc.date.issued2024
dc.identifier.issn0048-9697
dc.identifier.urihttps://hdl.handle.net/11250/3144084
dc.description.abstractMost of the polycyclic aromatic hydrocarbons (PAHs) in petroleum are alkylated (alkyl PAHs), still the metabolism of these alkyl PAHs to the expected acid products (polycyclic aromatic acids; PAAs) has yet to be demonstrated in oil-exposed fish. Should these compounds be discovered in fish as they have in ragworm, rodents, and humans, they could present an indicative biomarker for assessing oil pollution. In this study, the ability to biotransform alkyl PAHs to PAAs was examined on Atlantic haddock (Melanogrammus aeglefinus). Exposure to phenanthrene, 1-methyphenanthrene or 1,4-dimethylphenanthrene was performed via intraperitoneal injection. An Ion Mobility Quadrupole Time-Of-Flight Mass Spectrometer (IMS-Q-TOF MS) was used in exploratory analysis of extracted bile samples. Acquisition of four-dimensional information by coupling liquid chromatography with the IMS-Q-TOF MS and in-silico prediction for feature prioritization in the data processing workflow allowed several tentative identifications with high degree of confidence. This work presents the first detection of PAAs in fish and suggests the importance of investigating alkyl PAHs in ecotoxicological studies of oil-polluted fish environments.en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleDiscovery of polycyclic aromatic acid metabolites in fish exposed to the petroleum compounds 1-methylphenanthrene and 1,4-dimethylphenanthreneen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2024 The Author(s)en_US
dc.source.articlenumber170496en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2
dc.identifier.doi10.1016/j.scitotenv.2024.170496
dc.identifier.cristin2247295
dc.source.journalScience of the Total Environmenten_US
dc.identifier.citationScience of the Total Environment. 2024, 918, 170496.en_US
dc.source.volume918en_US


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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal