Vis enkel innførsel

dc.contributor.authorOnken, Annette
dc.contributor.authorAboud, Said
dc.contributor.authorJørstad, Melissa Davidsen
dc.contributor.authorJenum, Pål
dc.contributor.authorBlomberg, Bjørn
dc.date.accessioned2024-08-16T07:25:13Z
dc.date.available2024-08-16T07:25:13Z
dc.date.created2016-01-08T12:19:30Z
dc.date.issued2015
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/11250/3146719
dc.description.abstractBackground: Bloodstream infections (BSI) are frequent and cause high case-fatality rates. Urgent antibiotic treatment can save patients’ lives, but antibiotic resistance can render antibiotic therapy futile. This study is the first to collect epidemiological data on BSI from Unguja, Zanzibar. Methods: Clinical data and blood for culturing and susceptibility testing of isolated microbes were obtained from 469 consecutively enrolled neonates, children and adults presenting with signs of systemic infections at Mnazi Mmoja Hospital (MMH), Zanzibar. Results: Pathogenic bacteria were recovered from the blood of 14% of the patients (66/469). The most frequently isolated microbes were Klebsiella pneumoniae, Escherichia coli, Acinetobacter spp. and Staphylococcus aureus. Infections were community-acquired in 56 patients (85%) and hospital-acquired in 8 (12%) (data missing for 2 patients). BSI caused by extended-spectrum beta-lactamase (ESBL) producing Enterobacteriaceae (E. coli, K. pneumoniae) was found in 5 cases, of which 3 were community-acquired and 2 hospital-acquired. Three of these patients died. Six of 7 Salmonella Typhi isolates were multidrug resistant. Streptococcus pneumoniae was found in one patient only. Conclusions: This is the first report of ESBL-producing bacteria causing BSI from the Zanzibar archipelago. Our finding of community-acquired BSI caused by ESBL-producing bacteria is alarming, as it implies that these difficult-to-treat bacteria have already spread in the society. In the local setting these infections are virtually impossible to cure. The findings call for increased awareness of rational antibiotic use, infection control and surveillance to counteract the problem of emerging antimicrobial resistance.en_US
dc.language.isoengen_US
dc.publisherPLoSen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titlePrevalence and antimicrobial resistance of microbes causing bloodstream infections in Unguja, Zanzibaren_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2015 the authorsen_US
dc.source.articlenumbere0145632en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.doi10.1371/journal.pone.0145632
dc.identifier.cristin1308566
dc.source.journalPLOS ONEen_US
dc.identifier.citationPLOS ONE. 2015, 10 (12), e0145632.en_US
dc.source.volume10en_US
dc.source.issue12en_US


Tilhørende fil(er)

Thumbnail

Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel

Navngivelse 4.0 Internasjonal
Med mindre annet er angitt, så er denne innførselen lisensiert som Navngivelse 4.0 Internasjonal