Blar i Department of Chemistry på forfatter "Fossen, Torgils"
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Acylated Flavone O-Glucuronides from the Aerial Parts of Nepeta curviflora
Rabee, Maysaa; Andersen, Øyvind M; Fossen, Torgils; Enerstvedt, Kjersti Hasle; Ali, Hijazi Abu; Rayyan, Saleh (Journal article; Peer reviewed, 2020)Nepeta curviflora Boiss. (Syrian catnip) is native to the Middle East. This medicinal plant is commonly used against nervous disorders, rheumatic pains, and high blood pressure. Herbal infusions prepared from various Nepeta ... -
Cytotoxic Natural Products Isolated from Cryptogramma crispa (L.) R. Br.
Carpinteyro Diaz, Andrea Estefania; Herfindal, Lars; Andersen, Heidi Lie; Fossen, Torgils (Journal article; Peer reviewed, 2023)Parsley fern, Cryptogramma crispa, is a common fern in arctic–alpine regions, and even though this species has been known since ancient times and has been presumed to cause the poisoning of horses, its natural products ... -
Cytotoxic saponins and other natural products from flowering tops of Narthecium ossifragum L
Carpinteyro Diaz, Andrea Estefania; Herfindal, Lars; Rathe, Bendik Auran; Sletta, Kristine; Vedeler, Anni; Haavik, Svein; Fossen, Torgils (Peer reviewed; Journal article, 2019)For more than four centuries, the intake of Narthecium ossifragum has been associated with poisoning in domesticated animals. Saponins occurring in flowering tops of the plant are considered to cause kidney damage in calves. ... -
Design, synthesis, and biological evaluation of scaffold-based tripeptidomimetic antagonists for CXC chemokine receptor 4 (CXCR4)
Zachariassen, Zack Georg; Thiele, Stefanie; Berg, Erik; Rasmussen, Pernille; Fossen, Torgils; Rosenkilde, Mette M.; Våbenø, Jon; Haug, Bengt Erik (Journal article, 2014)Structure–activity relationship studies of the cyclopentapeptide CXCR4 antagonists (cyclo(-l-/d-Arg1-Arg2-2-Nal3-Gly4-d-Tyr5-)) suggest that the l-/d-Arg1-Arg2-2-Nal3 tripeptide sequence contained within these cyclopentapeptides ... -
Influence of chain length on the activity of tripeptidomimetic antagonists for CXC chemokine receptor 4 (CXCR4)
Baumann, Markus; Hussain, Mohammad Musarraf; Henne, Nina; Garrote, Daniel Moya; Karlshøj, Stefanie; Fossen, Torgils; Rosenkilde, Mette M.; Våbenø, Jon; Haug, Bengt Erik (Peer reviewed; Journal article, 2017-01)Here we report a series of close analogues of our recently published scaffold-based tripeptidomimetic CXCR4 antagonists, containing positively charged guanidino groups in R1 and R2, and an aromatic group in R3. While ... -
The intriguing Cyclophilin A-HIV-1 Vpr interaction: prolyl cis/trans isomerisation catalysis and specific binding
Solbak, Sara Marie Øie; Reksten, Tove Ragna; Wray, Victor; Bruns, Karsten; Horvli, Ole; Raae, Arnt Johan; Henklein, Petra; Henklein, Peter; Röder, Rene; Mitzner, David; Schubert, Ulrich; Fossen, Torgils (Peer reviewed; Journal article, 2010-10-04)Background: Cyclophilin A (CypA) represents a potential target for antiretroviral therapy since inhibition of CypA suppresses human immunodeficiency virus type 1 (HIV-1) replication, although the mechanism through which ... -
Isolation and Characterization of Larvicidal Phenolic Acids from Kotschya thymodora Leaves
Daniel, Innocent John; Innocent, Ester; Sempombe, Joseph; Mugoyela, Veronica; Fossen, Torgils (Journal article; Peer reviewed, 2020)Malaria is a vector borne disease responsible for high morbidity, mortality and poverty in many tropical and subtropical countries. The disease is transmitted through a bite from an infected female Anopheles mosquito, ... -
Mutation of the highly conserved ser-40 of the HIV-1 p6 gag protein to phe causes the formation of a hydrophobic patch, enhances membrane association, and polyubiquitination of gag
Hahn, Friedrich; Setz, Christian; Friedrich, Melanie; Rauch, Pia; Solbak, Sara Marie Øie; Frøystein, Nils Åge; Henklein, Petra; Votteler, Jörg; Fossen, Torgils; Schubert, Ulrich (Peer reviewed; Journal article, 2014-10-02)The HIV-1 p6 Gag protein contains two late assembly (l-) domains that recruit proteins of the endosomal sorting complex required for transport (ESCRT) pathway to mediate membrane fission between the nascent virion and the ... -
Natural Products from Leaves of the Ancient Iranian Medicinal Plant Echium amoenum Fisch. & C. A. Mey.
Jamnani, Mehdi Jafari; Holmelid, Bjarte; Vedeler, Anni; Parsian, Hoda H.; Andersen, Heidi Lie; Fossen, Torgils (Journal article; Peer reviewed, 2023-01-02)For several millennia, leaves of Echium amoenum Fisch. & C. A. Mey., an important Iranian medicinal plant with nutritional value as nutraceutical, have been used as tea for the treatment of several conditions, including ... -
Non-Polar Natural Products from Bromelia laciniosa, Neoglaziovia variegata and Encholirium spectabile (Bromeliaceae)
Juvik, Ole-Johan; Holmelid, Bjarte; Francis, George William; Andersen, Heidi Lie; De Oliveira, Ana Paula; De Oliveira, Raimundo Gon alves; Da Silva Almeida, Jackson Roberto Guedes; Fossen, Torgils (Peer reviewed; Journal article, 2017-09-06)Extensive regional droughts are already a major problem on all inhabited continents and severe regional droughts are expected to become an increasing and extended problem in the future. Consequently, extended use of available ... -
Novel GHB-derived natural products from European mistletoe (Viscum album)
Amer, Bashar; Juvik, Ole-Johan; Francis, George William; Fossen, Torgils (Peer reviewed; Journal article, 2013)Context: The European white-berry mistletoe [Viscum album L. (Loranthaceae)] is among the oldest known medicinal plants. At present the most important application of mistletoe extracts is in the treatment of cancer. However, ... -
A novel poly-oxygenated flavone glucoside from aerial parts of the Brazilian plant Neoglaziovia variegata (Bromeliaceae)
Ibrahim, Ayaan Hamdi Haji; Herfindal, Lars; Rathe, Bendik Auran; Andersen, Heidi Lie; Almeida, Jackson R. G. S.; Fossen, Torgils (Peer reviewed; Journal article, 2019)Neoglaziovia variegata is endemic to northeastern Brazil. The drought resistant plant produces edible fruits and is used as a fibre plant by rural communities in the Caatinga region where a variety of products are made ... -
Synthesis of a novel tripeptidomimetic scaffold and biological evaluation for CXC chemokine receptor 4 (CXCR4) antagonism
Baumann, Markus; Nome, Lina Marie; Zachariassen, Zack Georg; Karlshøj, Stepfanie; Fossen, Torgils; Rosenkilde, Mette M.; Våbenø, Jon; Haug, Bengt Erik (Peer reviewed; Journal article, 2017-07)We here report the preparation of a new 2,6,8-trisubstituted bicyclic tripeptidomimetic scaffold through TFA-mediated cyclization of a linear precursor containing three side chains. The introduction of a triphenylmethyl-protected ...