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dc.contributor.authorHaarr, Larsen_US
dc.contributor.authorNilsen, Arvid Een_US
dc.contributor.authorKnappskog, Peren_US
dc.contributor.authorLangeland, Ninaen_US
dc.date.accessioned2016-01-14T13:33:09Z
dc.date.available2016-01-14T13:33:09Z
dc.date.issued2014-02-06
dc.PublishedBMC Infectious Diseases 2014, 14(1:63)eng
dc.identifier.issn1471-2334
dc.identifier.urihttps://hdl.handle.net/1956/10960
dc.description.abstractBackground: Herpes simplex virus type 2 (HSV-2) is sexually transmitted, leading to blisters and ulcers in the genito-anal region. After primary infection the virus is present in a latent state in neurons in sensory ganglia. Reactivation and production of new viral particles can cause asymptomatic viral shedding or new lesions. Establishment of latency, maintenance and reactivation involve silencing of genes, continuous suppression of gene activities and finally gene activation and synthesis of viral DNA. The purpose of the present work was to study the genetic stability of the virus during these events. Methods: HSV-2 was collected from 5 patients with true primary and recurrent infections, and the genes encoding glycoproteins B,G,E and I were sequenced. Results: No nucleotide substitution was observed in any patient, indicating genetic stability. However, since the total number of nucleotides in these genes is only a small part of the total genome, we cannot rule out variation in other regions. Conclusions: Although infections of cell cultures and animal models are useful for studies of herpes simplex virus, it is important to know how the virus behaves in the natural host. We observed that several glycoprotein gene sequences are stable from primary to recurrent infection. However, the virus isolates from the different patients were genetically different.en_US
dc.language.isoengeng
dc.publisherBioMed Centraleng
dc.rightsAttribution CC BY 2.0eng
dc.rights.urihttp://creativecommons.org/licenses/by/2.0eng
dc.subjectPrimary and recurrent infections of humanseng
dc.subjectGenetic stability of HSV-2eng
dc.titleStability of glycoprotein gene sequences of herpes simplex virus type 2 from primary to recurrent human infection, and diversity of the sequences among patients attending an STD clinicen_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2015-11-25T09:45:23Z
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright Haarr et al.; licensee BioMed Central Ltd. 2014
dc.identifier.doihttps://doi.org/10.1186/1471-2334-14-63
dc.identifier.cristin1156009
dc.subject.nsiVDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Infeksjonsmedisin: 776
dc.subject.nsiVDP::Midical sciences: 700::Clinical medical sciences: 750::Communicable diseases: 776
dc.subject.nsiVDP::Medisinske fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk genetikk: 714
dc.subject.nsiVDP::Midical sciences: 700::Basic medical, dental and veterinary sciences: 710::Medical genetics: 714
dc.subject.nsiVDP::Medisinske Fag: 700en_US


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Attribution CC BY 2.0
Except where otherwise noted, this item's license is described as Attribution CC BY 2.0